Nucleic Acids Research, Vol 25, Issue 17 3428-3432, Copyright © 1997 by Oxford University Press
F Kagitani, Y Kuroiwa, S Wakana, T Shiroishi, N Miyoshi, S Kobayashi, M Nishida, T Kohda, T Kaneko-Ishino and F Ishino
We have established a systematic screen for imprinted genes using a
subtraction-hybridization method with day 8.5 fertilized and
parthenogenetic embryos. Two novel imprinted genes, Peg1/Mest and Peg3,
were identified previously by this method, along with the two known
imprinted genes, Igf2 and Snrpn. Recently three additional candidate
imprinted genes, Peg5-7 , were detected and Peg5 is analyzed further in
this study. The cDNA sequence of Peg5 is identical to Neuronatin, a gene
recently reported to be expressed mainly in the brain. Two novel spliced
forms were detected with some additional sequence in the middle of the
known Neuronatin sequences. All alternatively spliced forms of Peg5 were
expressed only from the paternal allele, confirmed using DNA polymorphism
in a subinterspecific cross. Peg5/Neuronatin maps to sub- distal Chr 2,
proximal to the previously established imprinted region where imprinted
genes cause abnormal shape and behavior in neonates.
ARTICLES
Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse
Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta- cho, Midori-ku, Yokohama-226, Japan.
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