Nucleic Acids Research, Vol 25, Issue 18 3580-3583, Copyright © 1997 by Oxford University Press
DJ Lipman
A substantial fraction of vertebrate mRNAs contain long conserved blocks in
their untranslated regions as well as long blocks without silent changes in
their protein coding regions. These conserved blocks are largely comprised
of unique sequence within the genome, leaving us with an important puzzle
regarding their function. A large body of experimental data shows that
these regions are associated with regulation of mRNA stability. Combining
this information with the rapidly accumulating data on endogenous antisense
transcripts, we propose that the conserved sequences form long perfect
duplexes with antisense transcripts. The formation of such duplexes may be
essential for recognition by post-transcriptional regulatory systems. The
conservation may then be explained by selection against the dominant
negative effect of allelic divergence.
REVIEWS
Making (anti)sense of non-coding sequence conservation
National Center for Biotechnology Information, National Library of Medicine, NIH, Building 38A 8N803, 8600 Rockville Pike, Bethesda, MD 20894, USA. lipman@ncbi.nlm.nih.gov
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