Nucleic Acids Research, Vol 25, Issue 18 3636-3642, Copyright © 1997 by Oxford University Press
GL Dianov, JF Houle, N Iyer, VA Bohr and EC Friedberg
The hereditary disease Cockayne syndrome (CS) is a complex clinical
syndrome characterized by arrested post-natal growth as well as
neurological and other defects. The CSA and CSB genes are implicated in
this disease. The clinical features of CS can also accompany the excision
repair-defective hereditary disorder xeroderma pigmentosum (XP) from
genetic complementation groups B, D or G. The XPB and XPD proteins are
subunits of RNA polymerase II (RNAP II) transcription factor IIH (TFIIH).
We show here that extracts of CS-A and CS-B cells, as well as those from
XP-B/CS cells, support reduced levels of RNAP II transcription in vitro and
that this feature is dependent on the state or quality of the template.
ARTICLES
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
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