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Nucleic Acids Research, Vol 25, Issue 18 3745-3746, Copyright © 1997 by Oxford University Press

ARTICLES

A transgenic mouse strain expressing four drug-selectable marker genes

KL Tucker, Y Wang, J Dausman and R Jaenisch
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Murine embryonic stem (ES) cells are commonly cultured on feeder layers of primary murine embryonic fibroblasts (MEFs). Because gene targeting experiments often involve sequential selection for multiple-drug resistance in single ES cell lines, we have developed a new mouse strain which represents an economical donor for the production of multiple-drug resistant MEFs. MEFs prepared from the DR-4 mouse strain displayed resistance to concentrations of the drugs G418, 6- thioguanine, puromycin and hygromycin well above those used normally for the selection of drug-resistant ES cells.
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