Nucleic Acids Research, Vol 25, Issue 19 3950-3954, Copyright © 1997 by Oxford University Press
O Camacho-Vanegas, F Weighardt, C Ghigna, F Amaldi, S Riva and G Biamonti
The hnRNP A1 transcript has a relatively short 5'- untranslated region
(UTR) starting with a pyrimidine tract similar to that of mRNAs encoded by
the TOP [terminal oligo(pyrimidine)] genes in vertebrates. Such genes code
for ribosomal proteins and for other proteins directly or indirectly
involved in the production and function of the translation apparatus. As
expected from the role of the pyrimidine tract in the translational
regulation of TOP mRNAs, the A1 mRNA is more efficiently loaded onto
polysomes in growing than in resting cells. On the other hand, a less
stringent regulation with respect to that of other TOP mRNAs is observed,
partially due to the presence of multiple transcription start sites within
the pyrimidine tract, where transcripts with shorter TOP sequences are less
sensitive to regulation. Thus, from the point of view of structural
features and translation behaviour the A1 mRNA can be included in the class
of TOP genes, suggesting a possible role of A1 in translation.
Interestingly, a TOP-like behaviour was observed for hnRNP I mRNA but not
for hnRNP C1/C2 and A2/B1 mRNAs, indicating the existence of two classes of
hnRNPs with different translational regulation.
ARTICLES
Growth-dependent and growth-independent translation of messengers for heterogeneous nuclear ribonucleoproteins
Dipartimento di Biologia, Universita di Roma 'Tor Vergata', Via della Ricerca Scientifica, 00133 Roma, Italy.
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