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Nucleic Acids Research, Vol 25, Issue 20 4106-4110, Copyright © 1997 by Oxford University Press

ARTICLES

Interaction of human recombination proteins Rad51 and Rad54

EI Golub, OV Kovalenko, RC Gupta, DC Ward and CM Radding
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. golub@biomed.med.yale.edu

The cDNA for human protein HsRad54, which is a structural homolog of Saccharomyces cerevisiae recombination/repair protein Rad54, was cloned and expressed in Escherichia coli. As demonstrated by analysis in vitro and in vivo, HsRad54 protein interacts with human Rad51 recombinase. The interaction is mediated by the N-terminal domain of HsRad54 protein, which interacts with both free and DNA-bound HsRad51 protein.
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