Nucleic Acids Research, Vol 25, Issue 21 4296-4300, Copyright © 1997 by Oxford University Press
ML Hastings, C Milcarek, K Martincic, ML Peterson and SH Munroe
The erbAalpha gene encodes two alpha-thyroid hormone receptor isoforms,
TRalpha1 and TRalpha2, which arise from alternatively processed mRNAs,
erbAalpha1 (alpha1) and erb alpha2 (alpha2). The splicing and alternative
polyadenylation patterns of these mRNAs resemble that of mRNAs encoding
different forms of immunoglobulin heavy chains, which are regulated at the
level of alternative processing during B cell differentiation. This study
examines the levels of erbAalpha mRNA in eight B cell lines representing
four stages of differentiation in order to determine whether regulation of
the alternatively processed alpha1 and alpha2 mRNAs parallels the
processing of immunoglobulin heavy chain mRNAs. Results show that the
pattern of alpha1 and alpha2 mRNA expression is clearly different from that
observed for immunoglobulin heavy chain mRNAs. B cell lines display
characteristic ratios of alpha1/alpha2 mRNA at distinct stages of
differentiation. Furthermore, expression of an overlapping gene,
Rev-ErbAalpha (RevErb), was found to correlate strongly with an increase in
the ratio of alpha1/alpha2 mRNA. These results suggest that alternative
processing of erbAalpha mRNAs is regulated by a mechanism which is distinct
from that regulating immunoglobulin mRNA. The correlation between RevErb
and erbAalpha mRNA is consistent with negative regulation of alpha2 via
antisense interactions with the complementary RevErb mRNA.
ARTICLES
Expression of the thyroid hormone receptor gene, erbAalpha, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels
Department of Biology, Marquette University, Milwaukee, WI 53233, USA.
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