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Nucleic Acids Research, Vol 25, Issue 5 1002-1008, Copyright © 1997 by Oxford University Press

ARTICLES

The fission yeast UVDR DNA repair pathway is inducible

S Davey, ML Nass, JV Ferrer, K Sidik, A Eisenberger, DL Mitchell and GA Freyer
Cancer Research Laboratories, Queen's University, Kingston, Canada K7L 3N6.

In addition to nucleotide excision repair (NER), the fission yeast Schizosaccharomyces pombe possesses a UV damage endonuclease (UVDE) for the excision of cyclobutane pyrimidine dimers and 6-4 pyrimidine pyrimidones. We have previously described UVDE as part of an alternative excision repair pathway, UVDR, for UV damage repair. The existence of two excision repair processes has long been postulated to exist in S.pombe, as NER-deficient mutants are still proficient in the excision of UV photoproducts. UVDE recognizes the phosphodiester bond immediately 5'of the UV photoproducts as the initiating event in this process. We show here that UVDE activity is inducible at both the level of uve1+ mRNA and UVDE enzyme activity. Further, we show that UVDE activity is regulated by the product of the rad12 gene.
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