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Nucleic Acids Research, Vol 25, Issue 8 1662-1663, Copyright © 1997 by Oxford University Press

ARTICLES

Simultaneous detection of near-field topographic and fluorescence images of human chromosomes via scanning near-field optical/atomic- force microscopy (SNOAM)

S Iwabuchi, H Muramatsu, N Chiba, Y Kinjo, Y Murakami, T Sakaguchi, K Yokoyama and E Tamiya
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa 923-12, Japan.

Scanning near-field optical/atomic-force microscopy (SNOAM) provided us with simultaneous topographical and optical images of human chromosomes using a sharp and bent optical fiber as a near-field optical probe. Native chromosomes were spread out onto a coverslip using the surface- spreading whole-mount method. The SNOAM system does not need pretreatment of samples such as metal coating or chemical immobilization. Near-field topographic and fluorescence images provided useful information on native chromosome structure.
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