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Nucleic Acids Research, Vol 25, Issue 9 1715-1719, Copyright © 1997 by Oxford University Press

ARTICLES

The winged-helix transcription factor Trident is expressed in cycling cells

W Korver, J Roose and H Clevers
Department of Immunology, University Hospital Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands. w.korver@lab.azu.nl

We describe the cloning and characterization of Trident , a novel member of the fork head/winged-helix family, from murine thymus. In the mouse embryo, the gene was expressed in all tissues, whereas in adult mice expression was only detected in the thymus. Further analysis revealed that Trident expression strictly correlated with cell cycling, independent of cell type. Timing of [3H]thymidine incorporation showed that mRNA and protein expression were strongly upregulated upon entry into the S phase of the cell cycle. Moreover, the protein was phosphorylated in M phase. PCR-mediated selection of optimal binding sites yielded a consensus motif resembling that of other family members. These results identify Trident as a transcription factor, which is likely involved in cell cycle-specific gene regulation.
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