Nucleic Acids Research, Vol 26, Issue 1 205-213, Copyright © 1998 by Oxford University Press
P Hainaut, T Hernandez, A Robinson, P Rodriguez-Tome, T Flores, M Hollstein, CC Harris and R Montesano
Since 1989, about 570 different p53 mutations have been identified in more
than 8000 human cancers. A database of these mutations was initiated by M.
Hollstein and C. C. Harris in 1990. This database originally consisted of a
list of somatic point mutations in the p 53 gene of human tumors and cell
lines, compiled from the published literature and made available in a
standard electronic form. The database is maintained at the International
Agency for Research on Cancer (IARC) and updated versions are released
twice a year (January and July). The current version (July 1997) contains
records on 6800 published mutations and will surpass the 8000 mark in the
January 1998 release. The database now contains information on somatic and
germline mutations in a new format to facilitate data retrieval. In
addition, new tools are constructed to improve data analysis, such as a
Mutation Viewer Java applet developed at the European Bioinformatics
Institute (EBI) to visualise the location and impact of mutations on p53
protein structure. The database is available in different electronic
formats at IARC (http://www.iarc. fr/p53/homepage.htm ) or from the EBI
server (http://www.ebi.ac.uk ). The IARC p53 website also provides reports
on database analysis and links with other p53 sites as well as with related
databases. In this report, we describe the criteria for inclusion of data,
the revised format and the new visualisation tools. We also briefly discuss
the relevance of p 53 mutations to clinical and biological questions.
ARTICLES
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France. hainaut@iarc.fr
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. A. Bertout, A. J. Majmundar, J. D. Gordan, J. C. Lam, D. Ditsworth, B. Keith, E. J. Brown, K. L. Nathanson, and M. C. Simon HIF2{alpha} inhibition promotes p53 pathway activity, tumor cell death, and radiation responses PNAS, August 25, 2009; 106(34): 14391 - 14396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Topisirovic, G. J. Gutierrez, M. Chen, E. Appella, K. L. B. Borden, and Z. A. Ronai Control of p53 multimerization by Ubc13 is JNK-regulated PNAS, August 4, 2009; 106(31): 12676 - 12681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sun, Y. Qiu, Z. Zhang, J. Wan, T. Wang, X. Jin, Q. Lan, N. Rothman, and Z.-l. Xia Association of Genetic Polymorphisms, mRNA Expression of p53 and p21 with Chronic Benzene Poisoning in a Chinese Occupational Population Cancer Epidemiol. Biomarkers Prev., June 1, 2009; 18(6): 1821 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. McCulloch, R. J. Kokoska, P. Garg, P. M. Burgers, and T. A. Kunkel The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases {delta} and {eta} Nucleic Acids Res., May 1, 2009; 37(9): 2830 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Wang, R. L. Hullinger, and O. M. Andrisani Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis J. Biol. Chem., September 12, 2008; 283(37): 25455 - 25467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Cuddihy, F. Jalali, C. Coackley, and R. G. Bristow WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells Mol. Cancer Ther., April 1, 2008; 7(4): 980 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Choi and J.N. Myers Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy Journal of Dental Research, January 1, 2008; 87(1): 14 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ruano-Ravina, R. Perez-Becerra, M. Fraga, K. T. Kelsey, and J. M. Barros-Dios Analysis of the relationship between p53 immunohistochemical expression and risk factors for lung cancer, with special emphasis on residential radon exposure Ann. Onc., January 1, 2008; 19(1): 109 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S.-Y. Foo, Y.-J. Nam, M. J. Ostreicher, M. D. Metzl, R. S. Whelan, C.-F. Peng, A. W. Ashton, W. Fu, K. Mani, S.-F. Chin, et al. Regulation of p53 tetramerization and nuclear export by ARC PNAS, December 26, 2007; 104(52): 20826 - 20831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Young, D. D. Weisenburger, B. J. Dave, L. Smith, W. Sanger, J. Iqbal, E. Campo, J. Delabie, R. D. Gascoyne, G. Ott, et al. Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma Blood, December 15, 2007; 110(13): 4396 - 4405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bodai, N. Pardi, Z. Ujfaludi, O. Bereczki, O. Komonyi, E. Balint, and I. M. Boros Daxx-like Protein of Drosophila Interacts with Dmp53 and Affects Longevity and Ark mRNA Level J. Biol. Chem., December 14, 2007; 282(50): 36386 - 36393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Ishii, J Murakami, K Notohara, H M Cullings, H Sasamoto, T Kambara, Y Shirakawa, Y Naomoto, M Ouchida, K Shimizu, et al. Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa Gut, January 1, 2007; 56(1): 13 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Laine, I. Topisirovic, D. Zhai, J. C. Reed, K. L. B. Borden, and Z. Ronai Regulation of p53 Localization and Activity by Ubc13 Mol. Cell. Biol., December 1, 2006; 26(23): 8901 - 8913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Goodson, W. J. Crookes-Goodson, J. R. Kimbell, and M. J. McFall-Ngai Characterization and Role of p53 Family Members in the Symbiont-Induced Morphogenesis of the Euprymna scolopes Light Organ. Biol. Bull., August 1, 2006; 211(1): 7 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Scian, K. E. R. Stagliano, M. A. E. Anderson, S. Hassan, M. Bowman, M. F. Miles, S. P. Deb, and S. Deb Tumor-Derived p53 Mutants Induce NF-{kappa}B2 Gene Expression Mol. Cell. Biol., November 15, 2005; 25(22): 10097 - 10110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Miller, J. Smeds, J. George, V. B. Vega, L. Vergara, A. Ploner, Y. Pawitan, P. Hall, S. Klaar, E. T. Liu, et al. From The Cover: An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival PNAS, September 20, 2005; 102(38): 13550 - 13555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.P. LANE Exploiting the p53 Pathway for the Diagnosis and Therapy of Human Cancer Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 489 - 497. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Kim, R. C. Sills, and C. D. Houle Overview of the Molecular Biology of Hepatocellular Neoplasms and Hepatoblastomas of the Mouse Liver Toxicol Pathol, January 1, 2005; 33(1): 175 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schlichtholz, M. Presler, and M. Matuszewski Clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast Carcinogenesis, December 1, 2004; 25(12): 2319 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Knights, Y. Liu, E. Appella, and M. Kulesz-Martin Defective p53 Post-translational Modification Required for Wild Type p53 Inactivation in Malignant Epithelial Cells with mdm2 Gene Amplification J. Biol. Chem., December 26, 2003; 278(52): 52890 - 52900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Itoh, C. O'Shea, and S. Linn Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48DDB2 and p53 Mol. Cell. Biol., November 1, 2003; 23(21): 7540 - 7553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Havrilesky, K. M. Darcy, H. Hamdan, R. L. Priore, J. Leon, J. Bell, and A. Berchuck Prognostic Significance of p53 Mutation and p53 Overexpression in Advanced Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study J. Clin. Oncol., October 15, 2003; 21(20): 3814 - 3825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Casson, S. C. Evans, A. Gillis, G. A. Porter, P. Veugelers, S. J. Darnton, D. L. Guernsey, and P. Hainaut Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: Results of a ten-year prospective study J. Thorac. Cardiovasc. Surg., May 1, 2003; 125(5): 1121 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Yoon, C.-S. Lee, and G. P. Pfeifer Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra Carcinogenesis, January 1, 2003; 24(1): 113 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brazdova, J. Palecek, D. I. Cherny, S. Billova, M. Fojta, P. Pecinka, B. Vojtesek, T. M. Jovin, and E. Palecek Role of tumor suppressor p53 domains in selective binding to supercoiled DNA Nucleic Acids Res., November 15, 2002; 30(22): 4966 - 4974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Weinberg and M. F. Denning P21WAF1 CONTROL OF EPITHELIAL CELL CYCLE AND CELL FATE Critical Reviews in Oral Biology & Medicine, November 1, 2002; 13(6): 453 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L L Barrow, H van Bokhoven, S Daack-Hirsch, T Andersen, S E C van Beersum, R Gorlin, and J C Murray Analysis of the p63 gene in classical EEC syndrome, related syndromes, and non-syndromic orofacial clefts J. Med. Genet., August 1, 2002; 39(8): 559 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamanishi, D. L. Boyle, S. Rosengren, D. R. Green, N. J. Zvaifler, and G. S. Firestein Regional analysis of p53 mutations in rheumatoid arthritis synovium PNAS, July 23, 2002; 99(15): 10025 - 10030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Leroy, C. Haioun, E. Lepage, N. Le Metayer, F. Berger, E. Labouyrie, V. Meignin, B. Petit, C. Bastard, G. Salles, et al. p53 gene mutations are associated with poor survival in low and low-intermediate risk diffuse large B-cell lymphomas Ann. Onc., July 1, 2002; 13(7): 1108 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Buzek, L. Latonen, S. Kurki, K. Peltonen, and M. Laiho Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277 Nucleic Acids Res., June 1, 2002; 30(11): 2340 - 2348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X P Hao, I M Frayling, J G Sgouros, M Q Du, T C Willcocks, I C Talbot, and I P M Tomlinson The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas Gut, June 1, 2002; 50(6): 834 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Megha, F Ferrari, A Benvenuto, C Bellan, A V Lalinga, S Lazzi, S Bartolommei, G Cevenini, L Leoncini, and P Tosi p53 mutation in breast cancer. Correlation with cell kinetics and cell of origin J. Clin. Pathol., June 1, 2002; 55(6): 461 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Boley, V. A. Wong, J. E. French, and L. Recio p53 Heterozygosity Alters the mRNA Expression of p53 Target Genes in the Bone Marrow in Response to Inhaled Benzene Toxicol. Sci., April 1, 2002; 66(2): 209 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shibata, J. Parsonnet, T. A. Longacre, M. I. Garcia, B. Puligandla, R.E. Davis, J. H. Vogelman, N. Orentreich, and L. A. Habel CagA status of Helicobacter pylori infection and p53 gene mutations in gastric adenocarcinoma Carcinogenesis, March 1, 2002; 23(3): 419 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Noori and S.-M. Hou Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers Carcinogenesis, November 1, 2001; 22(11): 1825 - 1830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ling, A. Persson, B. Berne, M. Uhlen, J. Lundeberg, and F. Ponten Persistent p53 Mutations in Single Cells from Normal Human Skin Am. J. Pathol., October 1, 2001; 159(4): 1247 - 1253. [Abstract] [Full Text]
|
|
|
|
|
|
A. K. Eapen, M. K. Henry, D. E. Quelle, and F. W. Quelle DNA Damage-Induced G1 Arrest in Hematopoietic Cells Is Overridden following Phosphatidylinositol 3-Kinase-Dependent Activation of Cyclin-Dependent Kinase 2 Mol. Cell. Biol., September 15, 2001; 21(18): 6113 - 6121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Hussain, P. Amstad, K. Raja, M. Sawyer, L. Hofseth, P. G. Shields, A. Hewer, D. H. Phillips, D. Ryberg, A. Haugen, et al. Mutability of p53 Hotspot Codons to Benzo(a)pyrene Diol Epoxide (BPDE) and the Frequency of p53 Mutations in Nontumorous Human Lung Cancer Res., September 1, 2001; 61(17): 6350 - 6355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Gruszka-Westwood, R. A. Hamoudi, E. Matutes, E. Tuset, and D. Catovsky p53 abnormalities in splenic lymphoma with villous lymphocytes Blood, June 1, 2001; 97(11): 3552 - 3558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ide, H. Oda, Y. Nakatsuru, K. Kusama, H. Sakashita, K. Tanaka, and T. Ishikawa Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis Carcinogenesis, April 1, 2001; 22(4): 567 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Biramijamal, A. Allameh, P. Mirbod, H.-J. Groene, R. Koomagi, and M. Hollstein Unusual Profile and High Prevalence of p53 Mutations in Esophageal Squamous Cell Carcinomas from Northern Iran Cancer Res., April 1, 2001; 61(7): 3119 - 3123. [Abstract] [Full Text]
|
|
|
|
|
|
D. H. Christiansen, M. K. Andersen, and J. Pedersen-Bjergaard Mutations With Loss of Heterozygosity of p53 Are Common in Therapy-Related Myelodysplasia and Acute Myeloid Leukemia After Exposure to Alkylating Agents and Significantly Associated With Deletion or Loss of 5q, a Complex Karyotype, and a Poor Prognosis J. Clin. Oncol., March 1, 2001; 19(5): 1405 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tada, K. Furuuchi, M. Kaneda, J. Matsumoto, M. Takahashi, A. Hirai, Y. Mitsumoto, R. D Iggo, and T. Moriuchi Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutants Carcinogenesis, March 1, 2001; 22(3): 515 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Capoulade, L. M. Mir, K. Carlier, Y. Lecluse, C. Tetaud, Z. Mishal, and J. Wiels Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides Blood, February 15, 2001; 97(4): 1043 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wingender, X. Chen, E. Fricke, R. Geffers, R. Hehl, I. Liebich, M. Krull, V. Matys, H. Michael, R. Ohnhauser, et al. The TRANSFAC system on gene expression regulation Nucleic Acids Res., January 1, 2001; 29(1): 281 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Soufir, L. Daya-Grosjean, P. de La Salmoniere, J.-P. Moles, L. Dubertret, A. Sarasin, and N. Basset-Seguin Association Between INK4a-ARF and p53 Mutations in Skin Carcinomas of Xeroderma Pigmentosum Patients J Natl Cancer Inst, November 15, 2000; 92(22): 1841 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Paschke Analysis of different versions of the IARC p53 database with respect to G->T transversion mutation frequencies and mutation hotspots in lung cancer of smokers and non-smokers Mutagenesis, November 1, 2000; 15(6): 457 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Deng and X. Wu Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria PNAS, October 24, 2000; 97(22): 12050 - 12055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Rugge, Y-H Shiao, G Busatto, M Cassaro, C Strobbe, V M Russo, G Leo, A R Parenti, A Scapinello, P Arslan, et al. The p53 gene in patients under the age of 40 with gastric cancer: mutation rates are low but are associated with a cardiac location Mol. Pathol., August 1, 2000; 53(4): 207 - 210. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Liefer, M. I. Koster, X.-J. Wang, A. Yang, F. McKeon, and D. R. Roop Down-Regulation of p63 Is Required for Epidermal UV-B-induced Apoptosis Cancer Res., August 1, 2000; 60(15): 4016 - 4020. [Abstract] [Full Text]
|
|
|
|
|
|
K. Husgafvel-Pursiainen, P. Boffetta, A. Kannio, F. Nyberg, G. Pershagen, A. Mukeria, V. Constantinescu, C. Fortes, and S. Benhamou p53 Mutations and Exposure to Environmental Tobacco Smoke in a Multicenter Study on Lung Cancer Cancer Res., June 1, 2000; 60(11): 2906 - 2911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Smith, M. F. Denissenko, W. P. Bennett, H. Li, S. Amin, M.-s. Tang, and G. P. Pfeifer Targeting of Lung Cancer Mutational Hotspots by Polycyclic Aromatic Hydrocarbons J Natl Cancer Inst, May 17, 2000; 92(10): 803 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. Wen, L. Bernstein, J. Lescallett, Y. Beazer-Barclay, J. Sullivan-Halley, M. White, and M. F. Press Comparison of TP53 Mutations Identified by Oligonucleotide Microarray and Conventional DNA Sequence Analysis Cancer Res., May 1, 2000; 60(10): 2716 - 2722. [Abstract] [Full Text]
|
|
|
|
|
|
V. Robert, P. Michel, J. M. Flaman, A. Chiron, C. Martin, F. Charbonnier, B. Paillot, and T. Frebourg High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis Carcinogenesis, April 1, 2000; 21(4): 563 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Mendrysa and M. E. Perry The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress Mol. Cell. Biol., March 15, 2000; 20(6): 2023 - 2030. [Abstract] [Full Text]
|
|
|
|
|
|
P. D. Castro, J. C. Liang, and L. Nagarajan Deletions of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms Blood, March 15, 2000; 95(6): 2138 - 2143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Monti, A. Inga, A. Aprile, P. Campomenosi, P. Menichini, L. Ottaggio, S. Viaggi, G. Ghigliotti, A. Abbondandolo, and G. Fronza p53 mutations experimentally induced by 8-methoxypsoralen plus UVA (PUVA) differ from those found in human skin cancers in PUVA-treated patients Mutagenesis, March 1, 2000; 15(2): 127 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Reis, D. L. Cheo, L. B. Meira, M. S. Greenblatt, J. P. Bond, D. Nahari, and E. C. Friedberg Genotype-specific Trp53 Mutational Analysis in Ultraviolet B Radiation-induced Skin Cancers in Xpc and Xpc Trp53 Mutant Mice Cancer Res., March 1, 2000; 60(6): 1571 - 1579. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Inazuka, T. Tahira, T. Horiuchi, S. Harashima, T. Sawabe, M. Kondo, H. Miyahara, and K. Hayashi Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium Rheumatology, March 1, 2000; 39(3): 262 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. N. Aurelio, X.-T. Kong, S. Gupta, and E. J. Stanbridge p53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines Mol. Cell. Biol., February 1, 2000; 20(3): 770 - 778. [Abstract] [Full Text]
|
|
|
|
|
|
P. A. Hall, S. J. Campbell, M. O'neill, D. J. Royston, K. Nylander, F. A. Carey, and N. M. Kernohan Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in normal and neoplasticcells Carcinogenesis, February 1, 2000; 21(2): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Servomaa, A Kiuru, V-M Kosma, P Hirvikoski, and T Rytömaa p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women Mol. Pathol., February 1, 2000; 53(1): 24 - 30. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Powell, R. Soong, B. Iacopetta, R. Seshadri, and D. R. Smith Prognostic Significance of Mutations to Different Structural and Functional Regions of the p53 Gene in Breast Cancer Clin. Cancer Res., February 1, 2000; 6(2): 443 - 451. [Abstract] [Full Text]
|
|
|
|
|
|
G. D. Kirk, A.-M. Camus-Randon, M. Mendy, J. J. Goedert, P. Merle, C. Trepo, C. Brechot, P. Hainaut, and R. Montesano Ser-249 p53 Mutations in Plasma DNA of Patients With Hepatocellular Carcinoma From The Gambia J Natl Cancer Inst, January 19, 2000; 92(2): 148 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Berggren, K. Hemminki, and G. Steineck p53 intron 7 polymorphisms in urinary bladder cancer patients and controls Mutagenesis, January 1, 2000; 15(1): 57 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tullo, A. M. D'Erchia, K. Honda, R. R. Mitry, M. D. Kelly, N. A. Habib, C. Saccone, and E. Sbisa Characterization of p53 Mutations in Colorectal Liver Metastases and Correlation with Clinical Parameters Clin. Cancer Res., November 1, 1999; 5(11): 3523 - 3528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Daigo, Y. Furukawa, T. Kawasoe, H. Ishiguro, M. Fujita, S. Sugai, S. Nakamori, G.-J. Liefers, R. A. E. M. Tollenaar, C. J. H. van de Velde, et al. Absence of Genetic Alteration at Codon 531 of the Human c-src Gene in 479 Advanced Colorectal Cancers from Japanese and Caucasian Patients Cancer Res., September 1, 1999; 59(17): 4222 - 4224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamamoto, A. Romanenko, M. Wei, C. Masuda, W. Zaparin, W. Vinnichenko, A. Vozianov, C. C. R. Lee, K. Morimura, H. Wanibuchi, et al. Specific p53 Gene Mutations in Urinary Bladder Epithelium after the Chernobyl Accident Cancer Res., August 1, 1999; 59(15): 3606 - 3609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Tammemagi, J. R. McLaughlin, and S. B. Bull Meta-Analyses of p53 Tumor Suppressor Gene Alterations and Clinicopathological Features in Resected Lung Cancers Cancer Epidemiol. Biomarkers Prev., July 1, 1999; 8(7): 625 - 634. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Kelly, A. Inga, F.-X. Chen, P. Dande, D. Shah, P. Monti, A. Aprile, P. A. Burns, G. Scott, A. Abbondandolo, et al. Relationship between DNA Methylation and Mutational Patterns Induced by a Sequence Selective Minor Groove Methylating Agent J. Biol. Chem., June 25, 1999; 274(26): 18327 - 18334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yngveson, C. Williams, A. Hjerpe, J. Lundeberg, P. Söderkvist, and G. Pershagen p53 Mutations in Lung Cancer Associated with Residential Radon Exposure Cancer Epidemiol. Biomarkers Prev., May 1, 1999; 8(5): 433 - 438. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. J. Bult, D. M. Krupke, B. J. Tennent, and J. T. Eppig A Survey of Web Resources for Basic Cancer Genetics Research Genome Res., May 1, 1999; 9(5): 397 - 408. [Full Text]
|
|
|
|
|
|
C. A. Klein, O. Schmidt-Kittler, J. A. Schardt, K. Pantel, M. R. Speicher, and G. Riethmuller Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells PNAS, April 13, 1999; 96(8): 4494 - 4499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gealy, L. Zhang, J. M. Siegfried, J. D. Luketich, and P. Keohavong Comparison of Mutations in the p53 and K-ras Genes in Lung Carcinomas from Smoking and Nonsmoking Women1 Cancer Epidemiol. Biomarkers Prev., April 1, 1999; 8(4): 297 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Husgafvel-Pursiainen, A. Karjalainen, A. Kannio, S. Anttila, T. Partanen, A. Ojajärvi, and H. Vainio Lung Cancer and Past Occupational Exposure to Asbestos . Role of p53 and K-ras Mutations Am. J. Respir. Cell Mol. Biol., April 1, 1999; 20(4): 667 - 674. [Abstract] [Full Text]
|
|
|
|
|
|
A. Inga, F.-X. Chen, P. Monti, A. Aprile, P. Campomenosi, P. Menichini, L. Ottaggio, S. Viaggi, A. Abbondandolo, B. Gold, et al. N-(2-Chloroethyl)-N-nitrosourea Tethered to Lexitropsin Induces Minor Groove Lesions at the p53 cDNA That Are More Cytotoxic than Mutagenic Cancer Res., February 1, 1999; 59(3): 689 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhou, X. W. Wang, L. Xu, K. Hagiwara, M. Nagashima, R. Wolkowicz, I. Zurer, V. Rotter, and C. C. Harris COOH-Terminal Domain of p53 Modulates p53-mediated Transcriptional Transactivation, Cell Growth, and Apoptosis Cancer Res., February 1, 1999; 59(4): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. H. N. Wong, Y. M. Dennis Lo, J. Zhang, C.-T. Liew, M. H. L. Ng, N. Wong, P. B. S. Lai, W. Y. Lau, N. M. Hjelm, and P. J. Johnson Detection of Aberrant p16 Methylation in the Plasma and Serum of Liver Cancer Patients Cancer Res., January 1, 1999; 59(1): 71 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kuhne and L. Banks E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box J. Biol. Chem., December 18, 1998; 273(51): 34302 - 34309. [Abstract] [Full Text] [PDF]
|
|