Nucleic Acids Research, Vol 26, Issue 1 94-99, Copyright © 1998 by Oxford University Press
SI Letovsky, RW Cottingham, CJ Porter and PWD Li
The Genome Database (GDB, http://www.gdb.org ) is a public repository of
data on human genes, clones, STSs, polymorphisms and maps. GDB entries are
highly cross-linked to each other, to literature citations and to entries
in other databases, including the sequence databases, OMIM, and the Mouse
Genome Database. Mapping data from large genome centers and smaller mapping
efforts are added to GDB on an ongoing basis. The database can be searched
by a variety of methods, ranging from keyword searches to complex queries.
Major functionality extensions in the last year include the ongoing
computation of integrated human genome maps, called Comprehensive Maps, and
the use of those maps to support positional queries and graphic displays.
The capabilities of the GDB map viewer (Mapview) have been extended to
include map printing and the graphical display of ad hoc query results. The
HUGO Nomenclature Committee continues to curate the proposed and official
gene symbols and related data in collaboration with GDB. As genome research
shifts its emphasis from mapping to sequencing and functional analysis, the
scope of the GDB schema is being extended. We are in the process of adding
representations of gene function and expression, and improving our
representation of human polymorphism and mutation.
ARTICLES
GDB: the Human Genome Database
Division of Biomedical Information Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2236, USA. letovsky@gdb.org
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