Nucleic Acids Research, Vol 26, Issue 12 2837-2842, Copyright © 1998 by Oxford University Press
JR Pehrson and RN Fuji
Histone macroH2A is an unusual core histone that contains a large non-
histone region, and a region that resembles a full length H2A. We examined
theconservation of this novel structural arrangement by cloning chicken
macroH2A cDNAs and comparing them to their rat counterparts. The amino acid
sequences of the two known macroH2A subtypes are >95% identical between
these species despite evolutionary separation of approximately 300 million
years. The H2A region of macroH2A is completely conserved, and thus is even
more conserved than conventional H2A in these species. The origin of the
non-histone domain was examined by comparing its sequence to proteins found
in bacteria and RNA viruses. These comparisons indicate that this domain is
derived from a gene that originated prior to the appearance of eukaryotes,
and suggest that the non-histone region has retained the basic function of
its ancestral gene.
ARTICLES
Evolutionary conservation of histone macroH2A subtypes and domains
University of Pennsylvania, Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA 19104-6048, USA. pehrson@vet.upenn.edu
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