Nucleic Acids Research, Vol 26, Issue 15 3453-3459, Copyright © 1998 by Oxford University Press
J Momand, D Jung, S Wilczynski and J Niland
The p53 tumor suppressor gene is inactivated in human tumors by several
distinct mechanisms. The best characterized inactivation mechanisms are:
(i) gene mutation; (ii) p53 protein association with viral proteins; (iii)
p53 protein association with the MDM2 cellular oncoprotein. The MDM2 gene
has been shown to be abnormally up-regulated in human tumors and tumor cell
lines by gene amplification, increased transcript levels and enhanced
translation. This communication presents a brief review of the spectrum of
MDM2 abnormalities in human tumors and compares the tissue distribution of
MDM2 amplification and p53 mutation frequencies. In this study, 3889
samples from tumors or xenografts from 28 tumor types were examined for
MDM2 amplification from previously published sources. The overall frequency
of MDM2 amplification in these human tumors was 7%. Gene amplification was
observed in 19 tumor types, with the highest frequency observed in soft
tissue tumors (20%), osteosarcomas (16%) and esophageal carcinomas (13%).
Tumors which showed a higher incidence of MDM2 amplification than p53
mutation were soft tissue tumors, testicular germ cell cancers and
neuro-blastomas. Data from studies where both MDM2 amplification and p53
mutations were analyzed within the same samples showed that mutations in
these two genes do not generally occur within the same tumor. In these
studies, 29 out of a total of 33 MDM2 amplification- positive tumors had
wild-type p53. We hypothesize that heretofore uncharacterized carcinogens
favor MDM2 amplification over p53 mutations in certain tumor types. A
database listing the MDM2 gene amplifications is available on the World
Wide Web at http://www. infosci.coh.org/mdm2 . Charts of MDM2 amplification
frequencies and comparisons with p53 genetic alterations are also available
at this Web site.
REVIEWS
The MDM2 gene amplification database
Department of Cell and Tumor Biology, Beckman Research Institute, National Medical Center, 1450 East Duarte Road, Duarte, CA 91010-3000, USA. jmomand@coh.org
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P.-C. Kuo, Y.-P. Tsao, H.-W. Chang, P.-H. Chen, C.-W. Huang, S.-T. Lin, Y.-T. Weng, T.-C. Tsai, S.-Y. Shieh, and S.-L. Chen Breast Cancer Amplified Sequence 2, a Novel Negative Regulator of the p53 Tumor Suppressor Cancer Res., December 1, 2009; 69(23): 8877 - 8885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Donehower Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity Cold Spring Harb Perspect Biol, December 1, 2009; 1(6): a001081 - a001081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Corcoran, J. Montalbano, H. Sun, Q. He, Y. Huang, and M. S. Sheikh Identification and Characterization of Two Novel Isoforms of Pirh2 Ubiquitin Ligase That Negatively Regulate p53 Independent of RING Finger Domains J. Biol. Chem., August 14, 2009; 284(33): 21955 - 21970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miyachi, N. Kakazu, S. Yagyu, Y. Katsumi, S. Tsubai-Shimizu, K. Kikuchi, K. Tsuchiya, T. Iehara, and H. Hosoi Restoration of p53 Pathway by Nutlin-3 Induces Cell Cycle Arrest and Apoptosis in Human Rhabdomyosarcoma Cells Clin. Cancer Res., June 15, 2009; 15(12): 4077 - 4084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Saha, M. Murakami, P. Kumar, B. Bajaj, K. Sims, and E. S. Robertson Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2 J. Virol., May 1, 2009; 83(9): 4652 - 4669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. R. Logan, H. V. McNeill, S. Cook, X. Lu, D. W. Meek, F. V. Fuller-Pace, J. Lunec, and C. N. Robson Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage Nucleic Acids Res., May 1, 2009; 37(9): 2962 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sur, R. Pagliarini, F. Bunz, C. Rago, L. A. Diaz Jr., K. W. Kinzler, B. Vogelstein, and N. Papadopoulos A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53 PNAS, March 10, 2009; 106(10): 3964 - 3969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bouska and C. M. Eischen Mdm2 Affects Genome Stability Independent of p53 Cancer Res., March 1, 2009; 69(5): 1697 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.N. V. Gopal, E. Chanchorn, and M. W. Van Dyke Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions Mol. Cancer Ther., March 1, 2009; 8(3): 552 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Sakamoto Targeting Ubiquitin and Ubiquitin-like Modifier Pathways for Cancer Therapy ASCO Educational Book, January 1, 2009; 2009(1): 171 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Bassett, W. Wang, F. Rastinejad, and W. S. El-Deiry Structural and Functional Basis for Therapeutic Modulation of p53 Signaling Clin. Cancer Res., October 15, 2008; 14(20): 6376 - 6386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shangary and S. Wang Targeting the MDM2-p53 Interaction for Cancer Therapy Clin. Cancer Res., September 1, 2008; 14(17): 5318 - 5324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Jones, Q. Chen, P. M. Voorhees, K. H. Young, N. Bruey-Sedano, D. Yang, and R. Z. Orlowski Inhibition of the p53 E3 Ligase HDM-2 Induces Apoptosis and DNA Damage-Independent p53 Phosphorylation in Mantle Cell Lymphoma Clin. Cancer Res., September 1, 2008; 14(17): 5416 - 5425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bouska, T. Lushnikova, S. Plaza, and C. M. Eischen Mdm2 Promotes Genetic Instability and Transformation Independent of p53 Mol. Cell. Biol., August 1, 2008; 28(15): 4862 - 4874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kitagaki, K. K. Agama, Y. Pommier, Y. Yang, and A. M. Weissman Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2 Mol. Cancer Ther., August 1, 2008; 7(8): 2445 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wang, Z. Zhang, H. Zhu, G. Fu, S. Wang, D. Wu, J. Zhou, Q. Wei, and Z. Zhang A Novel Functional Polymorphism C1797G in the MDM2 Promoter Is Associated with Risk of Bladder Cancer in a Chinese Population Clin. Cancer Res., June 1, 2008; 14(11): 3633 - 3640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lopez-Pajares, M. M. Kim, and Z.-M. Yuan Phosphorylation of MDMX Mediated by Akt Leads to Stabilization and Induces 14-3-3 Binding J. Biol. Chem., May 16, 2008; 283(20): 13707 - 13713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Shamanin, P. Sekaric, and E. J. Androphy hAda3 Degradation by Papillomavirus Type 16 E6 Correlates with Abrogation of the p14ARF-p53 Pathway and Efficient Immortalization of Human Mammary Epithelial Cells J. Virol., April 15, 2008; 82(8): 3912 - 3920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Sasiela, D. H. Stewart, J. Kitagaki, Y. J. Safiran, Y. Yang, A. M. Weissman, P. Oberoi, I. V. Davydov, E. Goncharova, J. A. Beutler, et al. Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen J Biomol Screen, March 1, 2008; 13(3): 229 - 237. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Forslund, Z. Zeng, L.-X. Qin, S. Rosenberg, M. Ndubuisi, H. Pincas, W. Gerald, D. A. Notterman, F. Barany, and P. B. Paty MDM2 Gene Amplification Is Correlated to Tumor Progression but not to the Presence of SNP309 or TP53 Mutational Status in Primary Colorectal Cancers Mol. Cancer Res., February 1, 2008; 6(2): 205 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D'Arcy, W. Maruwge, B. A. Ryan, and B. Brodin The Oncoprotein SS18-SSX1 Promotes p53 Ubiquitination and Degradation by Enhancing HDM2 Stability Mol. Cancer Res., January 1, 2008; 6(1): 127 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Xue, M. Haber, C. Flemming, G. M. Marshall, R. B. Lock, K. L. MacKenzie, K. V. Gurova, M. D. Norris, and A. V. Gudkov p53 Determines Multidrug Sensitivity of Childhood Neuroblastoma Cancer Res., November 1, 2007; 67(21): 10351 - 10360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Cheok, A. Dey, and D. P. Lane Cyclin-Dependent Kinase Inhibitors Sensitize Tumor Cells to Nutlin-Induced Apoptosis: a Potent Drug Combination Mol. Cancer Res., November 1, 2007; 5(11): 1133 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. V. Wang, M. Wade, E. Wong, Y.-C. Li, L. W. Rodewald, and G. M. Wahl Quantitative analyses reveal the importance of regulated Hdmx degradation for P53 activation PNAS, July 24, 2007; 104(30): 12365 - 12370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Duong, N. Boulle, S. Daujat, J. Chauvet, S. Bonnet, H. Neel, and V. Cavailles Differential Regulation of Estrogen Receptor {alpha} Turnover and Transactivation by Mdm2 and Stress-Inducing Agents Cancer Res., June 1, 2007; 67(11): 5513 - 5521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C.A. Graat, J. E. Carette, F. H.E. Schagen, L. T. Vassilev, W. R. Gerritsen, G. J.L. Kaspers, P. I.J.M. Wuisman, and V. W. van Beusechem Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of mouse double minute 2 and adenoviruses encoding p53 Mol. Cancer Ther., May 1, 2007; 6(5): 1552 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Gudkov and E. A. Komarova Dangerous habits of a security guard: the two faces of p53 as a drug target Hum. Mol. Genet., April 15, 2007; 16(R1): R67 - R72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. R. Binder A Novel Application for Murine Double Minute 2 Antagonists: The p53 Tumor Suppressor Network Also Controls Angiogenesis Circ. Res., January 5, 2007; 100(1): 13 - 14. [Full Text] [PDF]
|
|
|
|
|
|
T.-H. Cheng and S. N. Cohen Human MDM2 Isoforms Translated Differentially on Constitutive versus p53-Regulated Transcripts Have Distinct Functions in the p53/MDM2 and TSG101/MDM2 Feedback Control Loops Mol. Cell. Biol., January 1, 2007; 27(1): 111 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lopez-Knowles, S. Hernandez, M. Kogevinas, J. Lloreta, A. Amoros, A. Tardon, A. Carrato, S. Kishore, C. Serra, N. Malats, et al. The p53 Pathway and Outcome among Patients with T1G3 Bladder Tumors. Clin. Cancer Res., October 15, 2006; 12(20): 6029 - 6036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Yang, C. S. Zong, W. Xia, Y. Wei, M. Ali-Seyed, Z. Li, K. Broglio, D. A. Berry, and M.-C. Hung MDM2 Promotes Cell Motility and Invasiveness by Regulating E-Cadherin Degradation. Mol. Cell. Biol., October 1, 2006; 26(19): 7269 - 7282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Van Maerken, F. Speleman, J. Vermeulen, I. Lambertz, S. De Clercq, E. De Smet, N. Yigit, V. Coppens, J. Philippe, A. De Paepe, et al. Small-Molecule MDM2 Antagonists as a New Therapy Concept for Neuroblastoma Cancer Res., October 1, 2006; 66(19): 9646 - 9655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Barbieri, P. Mehta, Z. Chen, L. Zhang, A. Slack, S. Berg, and J. M. Shohet MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death. Mol. Cancer Ther., September 1, 2006; 5(9): 2358 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-S. Dai, D. Shi, Y. Jin, X.-X. Sun, Y. Zhang, S. R. Grossman, and H. Lu Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism J. Biol. Chem., August 25, 2006; 281(34): 24304 - 24313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ferrone, F. Perrone, E. Tamborini, M. S. Paneni, M. Fermeglia, S. Suardi, E. Pastore, D. Delia, M. A. Pierotti, S. Pricl, et al. Functional analysis and molecular modeling show a preserved wild-type activity of p53C238Y. Mol. Cancer Ther., June 1, 2006; 5(6): 1467 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. R. Jarnagin, D. S. Klimstra, M. Hezel, M. Gonen, Y. Fong, K. Roggin, K. Cymes, R. P. DeMatteo, M. D'Angelica, L. H. Blumgart, et al. Differential Cell Cycle-Regulatory Protein Expression in Biliary Tract Adenocarcinoma: Correlation With Anatomic Site, Pathologic Variables, and Clinical Outcome J. Clin. Oncol., March 1, 2006; 24(7): 1152 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Menin, M. C. Scaini, G. L. De Salvo, M. Biscuola, M. Quaggio, G. Esposito, C. Belluco, M. Montagna, S. Agata, E. D'Andrea, et al. Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J Natl Cancer Inst, February 15, 2006; 98(4): 285 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tovar, J. Rosinski, Z. Filipovic, B. Higgins, K. Kolinsky, H. Hilton, X. Zhao, B. T. Vu, W. Qing, K. Packman, et al. From the Cover: Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy PNAS, February 7, 2006; 103(6): 1888 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Harris Protein-protein interactions for cancer therapy PNAS, February 7, 2006; 103(6): 1659 - 1660. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kashatus, P. Cogswell, and A. S. Baldwin Expression of the Bcl-3 proto-oncogene suppresses p53 activation Genes & Dev., January 15, 2006; 20(2): 225 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Koblish, S. Zhao, C. F. Franks, R. R. Donatelli, R. M. Tominovich, L. V. LaFrance, K. A. Leonard, J. M. Gushue, D. J. Parks, R. R. Calvo, et al. Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo Mol. Cancer Ther., January 1, 2006; 5(1): 160 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Giglio, F. Mancini, F. Gentiletti, G. Sparaco, L. Felicioni, F. Barassi, C. Martella, A. Prodosmo, S. Iacovelli, F. Buttitta, et al. Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization Cancer Res., November 1, 2005; 65(21): 9687 - 9694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kojima, M. Konopleva, I. J. Samudio, M. Shikami, M. Cabreira-Hansen, T. McQueen, V. Ruvolo, T. Tsao, Z. Zeng, L. T. Vassilev, et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy Blood, November 1, 2005; 106(9): 3150 - 3159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hong, X. Miao, X. Zhang, F. Ding, A. Luo, Y. Guo, W. Tan, Z. Liu, and D. Lin The Role of P53 and MDM2 Polymorphisms in the Risk of Esophageal Squamous Cell Carcinoma Cancer Res., October 15, 2005; 65(20): 9582 - 9587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Arva, T. R. Gopen, K. E. Talbott, L. E. Campbell, A. Chicas, D. E. White, G. L. Bond, A. J. Levine, and J. Bargonetti A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells J. Biol. Chem., July 22, 2005; 280(29): 26776 - 26787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mani and E. P. Gelmann The Ubiquitin-Proteasome Pathway and Its Role in Cancer J. Clin. Oncol., July 20, 2005; 23(21): 4776 - 4789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Bond, W. Hu, and A. Levine A Single Nucleotide Polymorphism in the MDM2 Gene: From a Molecular and Cellular Explanation to Clinical Effect Cancer Res., July 1, 2005; 65(13): 5481 - 5484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W. van Beusechem, P. B. van den Doel, and W. R. Gerritsen Conditionally replicative adenovirus expressing degradation-resistant p53 for enhanced oncolysis of human cancer cells overexpressing murine double minute 2 Mol. Cancer Ther., June 1, 2005; 4(6): 1013 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, H. Yin, B. Farooqi, S. Sebti, A. D. Hamilton, and J. Chen p53 {alpha}-Helix mimetics antagonize p53/MDM2 interaction and activate p53 Mol. Cancer Ther., June 1, 2005; 4(6): 1019 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hernandez, S. Bea, M. Pinyol, G. Ott, T. Katzenberger, A. Rosenwald, F. Bosch, A. Lopez-Guillermo, J. Delabie, D. Colomer, et al. CDK4 and MDM2 Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-type INK4a/ARF Locus Cancer Res., March 15, 2005; 65(6): 2199 - 2206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhou, R. Frum, S. Deb, and S. P. Deb The Growth Arrest Function of the Human Oncoprotein Mouse Double Minute-2 Is Disabled by Downstream Mutation in Cancer Cells Cancer Res., March 1, 2005; 65(5): 1839 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Carvajal, C. Tovar, H. Yang, B. T. Vu, D. C. Heimbrook, and L. T. Vassilev Activation of p53 by MDM2 Antagonists Can Protect Proliferating Cells from Mitotic Inhibitors Cancer Res., March 1, 2005; 65(5): 1918 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Wang, R.-K. Lin, Y.-H. Tan, J.-T. Chen, C.-Y. Chen, and Y.-C. Wang Wild-Type p53 Overexpression and Its Correlation With MDM2 and p14ARF Alterations: An Alternative Pathway to Non-Small-Cell Lung Cancer J. Clin. Oncol., January 1, 2005; 23(1): 154 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sdek, H. Ying, H. Zheng, A. Margulis, X. Tang, K. Tian, and Z.-X. J. Xiao The Central Acidic Domain of MDM2 Is Critical in Inhibition of Retinoblastoma-mediated Suppression of E2F and Cell Growth J. Biol. Chem., December 17, 2004; 279(51): 53317 - 53322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shiraishi and P. E. Nielsen Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates Nucleic Acids Res., September 15, 2004; 32(16): 4893 - 4902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Chang, D. J. Freeman, and H. Wu PTEN Regulates Mdm2 Expression through the P1 Promoter J. Biol. Chem., July 9, 2004; 279(28): 29841 - 29848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, H. Wang, G. Prasad, M. Li, D. Yu, J. A. Bonner, S. Agrawal, and R. Zhang Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models Clin. Cancer Res., February 15, 2004; 10(4): 1263 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Vassilev, B. T. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, N. Kong, U. Kammlott, C. Lukacs, C. Klein, et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 Science, February 6, 2004; 303(5659): 844 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Onel and C. Cordon-Cardo MDM2 and Prognosis Mol. Cancer Res., January 1, 2004; 2(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Perry Mdm2 in the Response to Radiation Mol. Cancer Res., January 1, 2004; 2(1): 9 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-M. Kang, H.-N. Cho, J.-M. Ahn, S.-S. Lee, D.-I. Jeoung, C.-K. Cho, S. Bae, S.-J. Lee, and Y.-S. Lee Alteration of gene expression during radiation-induced resistance and tumorigenesis in NIH3T3 cells revealed by cDNA microarrays: involvement of MDM2 and CDC25B Carcinogenesis, January 1, 2004; 25(1): 123 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Knights, Y. Liu, E. Appella, and M. Kulesz-Martin Defective p53 Post-translational Modification Required for Wild Type p53 Inactivation in Malignant Epithelial Cells with mdm2 Gene Amplification J. Biol. Chem., December 26, 2003; 278(52): 52890 - 52900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Overholtzer, P. H. Rao, R. Favis, X.-Y. Lu, M. B. Elowitz, F. Barany, M. Ladanyi, R. Gorlick, and A. J. Levine The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability PNAS, September 30, 2003; 100(20): 11547 - 11552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bartl, J. Ban, H. Weninger, G. Jug, and H. Kovar A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene Nucleic Acids Res., February 15, 2003; 31(4): 1136 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sanchez-Beato, A. Sanchez-Aguilera, and M. A. Piris Cell cycle deregulation in B-cell lymphomas Blood, February 15, 2003; 101(4): 1220 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Badciong and A. L. Haas MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination J. Biol. Chem., December 13, 2002; 277(51): 49668 - 49675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Polsky, K. Melzer, C. Hazan, K. S. Panageas, K. Busam, M. Drobnjak, H. Kamino, J. G. Spira, A. W. Kopf, A. Houghton, et al. HDM2 Protein Overexpression and Prognosis in Primary Malignant Melanoma J Natl Cancer Inst, December 4, 2002; 94(23): 1803 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Ard, C. Chatterjee, S. Kunjibettu, L. R. Adside, L. E. Gralinski, and S. B. McMahon Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes Mol. Cell. Biol., August 15, 2002; 22(16): 5650 - 5661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Knauf, L. S. Ward, Y. E. Nikiforov, M. Nikiforova, E. Puxeddu, M. Medvedovic, T. Liron, D. Mochly-Rosen, and J. A. Fagin Isozyme-Specific Abnormalities of PKC in Thyroid Cancer: Evidence for Post-Transcriptional Changes in PKC Epsilon J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2150 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Alarcon-Vargas and Z.'e. Ronai p53-Mdm2--the affair that never ends Carcinogenesis, April 1, 2002; 23(4): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Lu, J. Lin, and J. Chen Expression of p14ARF Overcomes Tumor Resistance to p53 Cancer Res., March 1, 2002; 62(5): 1305 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sanchez-Aguilera, M. Sanchez-Beato, J. F. Garcia, I. Prieto, M. Pollan, and M. A. Piris p14ARF nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways Blood, February 15, 2002; 99(4): 1411 - 1418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dang, M.-L. Kuo, C. M. Eischen, L. Stepanova, C. J. Sherr, and M. F. Roussel The RING Domain of Mdm2 Can Inhibit Cell Proliferation Cancer Res., February 1, 2002; 62(4): 1222 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, L. Nan, D. Yu, S. Agrawal, and R. Zhang Antisense Anti-MDM2 Oligonucleotides As a Novel Therapeutic Approach to Human Breast Cancer: In Vitro and in Vivo Activities and Mechanisms Clin. Cancer Res., November 1, 2001; 7(11): 3613 - 3624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Polsky, B. C. Bastian, C. Hazan, K. Melzer, J. Pack, A. Houghton, K. Busam, C. Cordon-Cardo, and I. Osman HDM2 Protein Overexpression, but not Gene Amplification, is Related to Tumorigenesis of Cutaneous Melanoma Cancer Res., October 1, 2001; 61(20): 7642 - 7646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Capoulade, L. M. Mir, K. Carlier, Y. Lecluse, C. Tetaud, Z. Mishal, and J. Wiels Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides Blood, February 15, 2001; 97(4): 1043 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Taniere, G. Martel-Planche, D. Maurici, C. Lombard-Bohas, J.-Y. Scoazec, R. Montesano, F. Berger, and P. Hainaut Molecular and Clinical Differences between Adenocarcinomas of the Esophagus and of the Gastric Cardia Am. J. Pathol., January 1, 2001; 158(1): 33 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lin, X. Jin, C. Page, V. K. Sondak, G. Jiang, and R. K. Reynolds A Modified p53 Overcomes mdm2-mediated Oncogenic Transformation: A Potential Cancer Therapeutic Agent Cancer Res., October 1, 2000; 60(20): 5895 - 5901. [Abstract] [Full Text]
|
|
|
|
|
|
N. Vlatkovic, S. Guerrera, Y. Li, S. Linn, D. S. Haines, and M. T. Boyd MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase {varepsilon} Nucleic Acids Res., September 15, 2000; 28(18): 3581 - 3586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Pise-Masison, R. Mahieux, H. Jiang, M. Ashcroft, M. Radonovich, J. Duvall, C. Guillerm, and J. N. Brady Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-kappa B Pathway and Is Dependent on p53 Phosphorylation Mol. Cell. Biol., May 15, 2000; 20(10): 3377 - 3386. [Abstract] [Full Text]
|
|
|
|
|
|
M. Serrano The INK4a/ARF locus in murine tumorigenesis Carcinogenesis, May 1, 2000; 21(5): 865 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. WAHL and O. VAFA Genetic Instability, Oncogenes, and the p53 Pathway Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 511 - 520. [Abstract] [PDF]
|
|
|
|
|
|
F. Moretti, S. Nanni, A. Farsetti, M. Narducci, M. Crescenzi, S. Giuliacci, A. Sacchi, and A. Pontecorvi Effects of Exogenous p53 Transduction in Thyroid Tumor Cells with Different p53 Status J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 302 - 308. [Abstract] [Full Text]
|
|
|
|
|
|
K. Ichimura, M. B. Bolin, H. M. Goike, E. E. Schmidt, A. Moshref, and V. P. Collins Deregulation of the p14ARF/MDM2/p53 Pathway Is a Prerequisite for Human Astrocytic Gliomas with G1-S Transition Control Gene Abnormalities Cancer Res., January 1, 2000; 60(2): 417 - 424. [Abstract] [Full Text]
|
|
|
|
|
|
D. A. Sharp, S. A. Kratowicz, M. J. Sank, and D. L. George Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein J. Biol. Chem., December 31, 1999; 274(53): 38189 - 38196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Riemenschneider, R. Buschges, M. Wolter, J. Reifenberger, J. Bostrom, J. A. Kraus, U. Schlegel, and G. Reifenberger Amplification and Overexpression of the MDM4 (MDMX) Gene from 1q32 in a Subset of Malignant Gliomas without TP53 Mutation or MDM2 Amplification Cancer Res., December 1, 1999; 59(24): 6091 - 6096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Bult, D. M. Krupke, B. J. Tennent, and J. T. Eppig A Survey of Web Resources for Basic Cancer Genetics Research Genome Res., May 1, 1999; 9(5): 397 - 408. [Full Text]
|
|