Nucleic Acids Research, Vol 26, Issue 16 3619-3625, Copyright © 1998 by Oxford University Press
CC Zhang, L Gonzalez and V Phalip
Bacteria usually use two-component systems for signal transduction, while
eukaryotic organisms employ Ser/Thr and Tyr kinases and phosphatases for
the same purpose. Many prokaryotes turn out to harbor Ser/Thr and Tyr
kinases, Ser/Thr and Tyr phosphatases, and their accessory components as
well. The sequence determination of the genome of the cyanobacterium
Synechocystis sp. strain PCC 6803 offers the possibility to survey the
extent of such molecules in a prokaryotic organism. This cyanobacterium
possesses seven Ser/Thr kinases, seven Ser/Thr and Tyr phosphatases, one
protein kinase interacting protein, one protein kinase regulatory subunit
and several WD40-repeat- containing proteins. The majority of the protein
phosphatases presented in this study were previously reported as
hypothetical proteins. We analyze here the structure and genetic
organization of these ORFs in the hope of providing a guidance for their
functional analysis. Unlike their eukaryotic counterparts, many of these
genes are clustered on the chromosome, and this genetic organization offers
the opportunity to study their possible interaction. In several cases,
genes of two- component transducers are found within the same cluster as
those encoding a Ser/Thr kinase or a Ser/Thr phosphatase; the implication
for signal transduction mechanism will be discussed.
REVIEWS
Survey, analysis and genetic organization of genes encoding eukaryotic- like signaling proteins on a cyanobacterial genome
Unite d'Immunotechnologie et Microbiologie Moleculaires, Ecole Superieure de Biotechnologie de Strasbourg, Universite Louis Pasteur de Strasbourg, Boulevard Sebastien Brandt, F-67400 Illkirch, France. cheng- cai.zhang@esbs.u-strasbg.fr
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