Nucleic Acids Research, Vol 26, Issue 16 3776-3783, Copyright © 1998 by Oxford University Press
YL Yao, BR Dupont, S Ghosh, Y Fang, RJ Leach and E Seto
Yin Yang 1 (YY1) is a protein that activates and represses transcription of
a large number of cellular and viral genes. In addition, studies suggest
that YY1 may play an important role in development and differentiation.
Here, we report the isolation and analysis of a YY1 genomic clone from a
lambda human liver library. Fluorescence in situ hybridization with the YY1
clone has localized the YY1 gene to chromosome 14 band q32. A major YY1
gene transcription initiation site has been mapped to 478 bp upstream of
the ATG translation start site. The proximal promoter contains multiple Sp1
transcription factor binding sites but lacks a consensus TATA or CCAAT box.
Transient transfections and detailed deletion analyses localized the
promoter to no more than 277 bp upstream from the major transcription start
site. Finally, we have found that overexpression of the adenovirus E1A
protein represses expression of a reporter gene directed by the YY1
promoter.
ARTICLES
Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1
H. Lee Moffitt Cancer Center and Research Institute, Department of Microbiology and Immunology, College of Medicine, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA.
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