Nucleic Acids Research, Vol 26, Issue 18 4093-4099, Copyright © 1998 by Oxford University Press
ES Haas and JW Brown
Sequences encoding RNase P RNAs from representatives of the last remaining
classical phyla of Bacteria have been determined, completing a general
phylogenetic survey of RNase P RNA sequence and structure. This broad
sampling of RNase P RNAs allows some refinement of the secondary structure,
and reveals patterns in the evolutionary variation of sequences and
secondary structures. Although the sequences range from 100 to <25%
identical to one another, and although only 40 of the nucleotides are
invariant, there is considerable conservation of the underlying core of the
RNA sequence. RNase P RNAs, like group I intron RNAs but unlike ribosomal
RNAs, transfer RNAs or other highly conserved RNAs, are quite variable in
secondary structure outside of this conserved structural core. Conservative
regions of the RNA evolve by substitution of apparently interchangeable
alternative structures, rather than the insertion and deletion of helical
elements that occurs in the more variable regions of the RNA. In a
remarkable case of convergent molecular evolution, most of the unusual
structural elements of type B RNase P RNAs of the low G+C Gram-positive
Bacteria have evolved independently in Thermomicrobium roseum , a member of
the green non-sulfur Bacteria.
ARTICLES
Evolutionary variation in bacterial RNase P RNAs
Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA.
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