Nucleic Acids Research, Vol 26, Issue 18 4196-4204, Copyright © 1998 by Oxford University Press
V Burland, Y Shao, NT Perna, G Plunkett, HJ Sofia and FR Blattner
The complete DNA sequence of pO157, the large virulence plasmid of EHEC
strain O157:H7 EDL 933, is presented. The 92 kb F-like plasmid is composed
of segments of putative virulence genes in a framework of replication and
maintenance regions, with seven insertion sequence elements, located mostly
at the boundaries of the virulence segments. One hundred open reading
frames (ORFs) were identified, of which 19 were previously sequenced
potential virulence genes. Forty-two ORFs were sufficiently similar to
known proteins for suggested functions to be assigned, and 22 had no
convincing similarity with any known proteins. Of the newly identified
genes, an unusually large ORF of 3169 amino acids has a putative cytotoxin
active site shared with the large clostridial toxin (LCT) family and
proteins such as ToxA and B of Clostridium difficile . A conserved motif
was detected that links the large ORF and the LCT proteins with the OCH1
family of glycosyltransferases. In the complete sequence, the mosaic form
can be observed at the levels of base composition, codon usage and gene
organization. Insights were obtained from patterns of DNA composition as
well as the pathogenic and 'housekeeping' gene segments. Evolutionary trees
built from shared plasmid maintenance genes show that even these genes have
heterogeneous origins.
ARTICLES
The complete DNA sequence and analysis of the large virulence plasmid of Escherichia coli O157:H7
Laboratory of Genetics, University of Wisconsin, 445 Henry Mall, Madison, WI 53706, USA. ecoli@genetics.wisc.edu
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