Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (258K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Slesarev, A. I.
Right arrow Articles by Lake, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Slesarev, A. I.
Right arrow Articles by Lake, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, Vol 26, Issue 2 427-430, Copyright © 1998 by Oxford University Press

ARTICLES

Evidence for an early prokaryotic origin of histones H2A and H4 prior to the emergence of eukaryotes

AI Slesarev, GI Belova, SA Kozyavkin and JA Lake
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117871 Moscow, Russia. slesarev@ibch.siobc.ras.ru

Histones have been identified recently in many prokaryotes. These histones, unlike their eukaryotic homologs, are of a single uniform type that is thought to resemble the archetypal ancestor of the eukaryotic histone family. In this paper we report the finding, the cloning and the phylogenetic analysis of the sequence of a prokaryotic histone from the hyperthermophile Methanopyrus kandleri . Unlike previously described prokaryotic histones, the Methanopyrus sequence has a novel structure consisting of two tandemly repeated histone fold motifs in a single polypeptide. Sequence analyses indicate that the N- terminal repeat is most closely related to eukaryotic H2A and H4 histones, whereas the C-terminal repeat resembles that found in prokaryotic histones. These results imply an early divergence within the histone gene family prior to the emergence of eukaryotes and may represent an evolutionary step leading to eukaryotic histones.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Bacteriol.Home page
N. Altman-Price and M. Mevarech
Genetic Evidence for the Importance of Protein Acetylation and Protein Deacetylation in the Halophilic Archaeon Haloferax volcanii
J. Bacteriol., March 1, 2009; 191(5): 1610 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. Gribaldo and C. Brochier-Armanet
The origin and evolution of Archaea: a state of the art
Phil Trans R Soc B, June 29, 2006; 361(1470): 1007 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. I. Slesarev, K. V. Mezhevaya, K. S. Makarova, N. N. Polushin, O. V. Shcherbinina, V. V. Shakhova, G. I. Belova, L. Aravind, D. A. Natale, I. B. Rogozin, et al.
The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens
PNAS, April 2, 2002; 99(7): 4644 - 4649.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
N. A. Pavlov, D. I. Cherny, I. V. Nazimov, A. I. Slesarev, and V. Subramaniam
Identification, cloning and characterization of a new DNA-binding protein from the hyperthermophilic methanogen Methanopyrus kandleri
Nucleic Acids Res., February 1, 2002; 30(3): 685 - 694.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. Sullivan, D. W. Sink, K. L. Trout, I. Makalowska, P. M. Taylor, A. D. Baxevanis, and D. Landsman
The Histone Database
Nucleic Acids Res., January 1, 2002; 30(1): 341 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. I. Belova, R. Prasad, S. A. Kozyavkin, J. A. Lake, S. H. Wilson, and A. I. Slesarev
A type IB topoisomerase with DNA repair activities
PNAS, May 22, 2001; 98(11): 6015 - 6020.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.