Nucleic Acids Research, Vol 26, Issue 2 469-476, Copyright © 1998 by Oxford University Press
J Roose, W Korver, E Oving, A Wilson, G Wagenaar, M Markman, W Lamers and H Clevers
Members of the Sox gene family of transcription factors are defined by the
presence of an 80 amino acid homology domain, the High Mobility Group (HMG)
box. Here we report the cloning and initial analysis of murine Sox-13 . The
984 amino acids Sox-13 protein contains a single HMG box, a leucine zipper
motif and a glutamine-rich stretch. These characteristics are shared with
another member of the Sox gene family, Sox-6. High level embryonic
expression of Sox-13 occurs uniquely in the arterial walls of 13.5 days
post coitum (dpc) mice and later. Low level expression was observed in the
inner ear of 13.5 dpc mice and in a limited number of cells in the thymus
of 16.5 dpc mice, from which Sox- 13 was originally cloned. At 18.5 dpc,
Sox-13 is expressed in the tracheal epithelium below the vocal cord and in
the hair follicles. The Sox-13 protein binds to the consensus HMG box
motif, AACAAAG, but does not transactivate transcription through a
concatamer of this motif. Sox- 13, like other members of the Sox family
likely plays an important role in development.
ARTICLES
High expression of the HMG box factor sox-13 in arterial walls during embryonic development
Department of Immunology, University Hospital, PO box 85500, 3508 GA, Utrecht, The Netherlands. j.roose@lab.azu.nl
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