Nucleic Acids Research, Vol 26, Issue 22 5045-5051, Copyright © 1998 by Oxford University Press
K Shiba, H Motegi, M Yoshida and T Noda
We have cloned and sequenced a cDNA encoding human cytoplasmic
asparaginyl-tRNA synthetase (AsnRS). The N-terminal appended domain of 112
amino acid represents the signature sequence for the eukaryotic AsnRS and
is absent from archaebacterial or eubacterial enzymes. The canonical
ortholog for AsnRS is absent from most archaebacterial and some eubacterial
genomes, indicating that in those organisms, formation of asparaginyl-tRNA
is independent of the enzyme. The high degree of sequence conservation
among asparaginyl- and aspartyl-tRNA synthetases (AsxRS) made it possible
to infer the evolutionary paths of the two enzymes. The data show the
neighbor relationship between AsnRS and eubacterial aspartyl-tRNA
synthetase, and support the occurrence of AsnRS early in the course of
evolution, which is in contrast to the proposed late occurrence of
glutaminyl-tRNA synthetase.
ARTICLES
Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family
Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1 Kami-Ikebukuro, Toshima, Tokyo 170-8455, Japan. kshiba@jfcr.or.jp
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