Nucleic Acids Research, Vol 26, Issue 3 761-767, Copyright © 1998 by Oxford University Press
Z Avramova, A Tikhonov, M Chen and JL Bennetzen
In order to gain insights into the relationship between spatial
organization of the genome and genome function we have initiated studies of
the co-linear Sh2/A1- homologous regions of rice (30 kb) and sorghum (50
kb). We have identified the locations of matrix attachment regions (MARs)
in these homologous chromosome segments, which could serve as anchors for
individual structural units or loops. Despite the fact that the nucleotide
sequences serving as MARs were not detectably conserved, the general
organizational patterns of MARs relative to the neighboring genes were
preserved. All identified genes were placed in individual loops that were
of comparable size for homologous genes. Hence, gene composition, gene
orientation, gene order and the placement of genes into structural units
has been evolutionarily conserved in this region. Our analysis demonstrated
that the occurrence of various 'MAR motifs' is not indicative of MAR
location. However, most of the MARs discovered in the two genomic regions
were found to co-localize with miniature inverted repeat transposable
elements (MITEs), suggesting that MITEs preferentially insert near MARs
and/or that they can serve as MARs.
ARTICLES
Matrix attachment regions and structural colinearity in the genomes of two grass species
Department of Biological Sciences and Purdue Genetics Program, Purdue University, West Lafayette, IN 47907, USA. zavramov@bilbo.bio.purdue.edu
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