Nucleic Acids Research, Vol 26, Issue 6 1433-1439, Copyright © 1998 by Oxford University Press
F Mantovani, S Covaceuszach, A Rustighi, R Sgarra, C Heath, GH Goodwin and G Manfioletti
High mobility group I proteins (HMGI, HMGY and HMGI-C) are a family of low
molecular mass non-histone nuclear proteins which constitute an important
component of the active chromatin structure. Two members of this family,
HMGI and HMGY, have been demonstrated to contribute to the transcriptional
regulation of several promoters by interacting with the DNA and with
different transcription factors. On the contrary, very little is known
about the third member, HMGI-C, which plays an important role during
embryonic growth and in the process of cell transformation, its gene being
rearranged in a large number of mesenchimal tumors. In this paper we show
for the first time that HMGI- C is also able to function as architectural
factor, enhancing the activity of a transcription factor, NF-kappaB,
through the PRDII element of the beta-interferon enhancer. Moreover we show
that this enhancement is absolutely dependent on the binding of HMGI-C to
its target sequence. The demonstration that HMGI-C is able to modulate
transcription is thus an important initial step in the identification of
genes regulated by this factor.
ARTICLES
NF-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, via Giorgieri, 134127 Trieste, Italy.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Cleynen, J. R. Brants, K. Peeters, R. Deckers, M. Debiec-Rychter, R. Sciot, W. J.M. Van de Ven, and M. M.R. Petit HMGA2 Regulates Transcription of the Imp2 Gene via an Intronic Regulatory Element in Cooperation with Nuclear Factor-{kappa}B Mol. Cancer Res., April 1, 2007; 5(4): 363 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sgarra, J. Lee, M. A. Tessari, S. Altamura, B. Spolaore, V. Giancotti, M. T. Bedford, and G. Manfioletti The AT-hook of the Chromatin Architectural Transcription Factor High Mobility Group A1a Is Arginine-methylated by Protein Arginine Methyltransferase 6 J. Biol. Chem., February 17, 2006; 281(7): 3764 - 3772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R.M.O. Crombez, E. M.R. Vanoirbeek, W. J.M. Van de Ven, and M. M.R. Petit Transactivation Functions of the Tumor-Specific HMGA2/LPP Fusion Protein Are Augmented by Wild-Type HMGA2 Mol. Cancer Res., February 1, 2005; 3(2): 63 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Tessari, M. Gostissa, S. Altamura, R. Sgarra, A. Rustighi, C. Salvagno, G. Caretti, C. Imbriano, R. Mantovani, G. Del Sal, et al. Transcriptional Activation of the Cyclin A Gene by the Architectural Transcription Factor HMGA2 Mol. Cell. Biol., December 15, 2003; 23(24): 9104 - 9116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Edelstein, L. Lagos, M. Simmons, H. Tirumalai, and C. Gelinas NF-{kappa}B-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1 Mol. Cell. Biol., April 15, 2003; 23(8): 2749 - 2761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Crinelli, M. Bianchi, L. Gentilini, and M. Magnani Design and characterization of decoy oligonucleotides containing locked nucleic acids Nucleic Acids Res., June 1, 2002; 30(11): 2435 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Schiltz, K. Kesari, H. R. Ashar, and K. Chada Hmgi-c-independent Activation of MuRantes in Vivo Cell Growth Differ., January 1, 2002; 13(1): 39 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fedele, S. Battista, G. Manfioletti, C. M. Croce, V. Giancotti, and A. Fusco Role of the high mobility group A proteins in human lipomas Carcinogenesis, October 1, 2001; 22(10): 1583 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. BRUNETTI, G. MANFIOLETTI, E. CHIEFARI, I. D. GOLDFINE, and D. FOTI Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y) FASEB J, February 1, 2001; 15(2): 492 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schwanbeck, G. Manfioletti, and J. R. Wisniewski Architecture of High Mobility Group Protein I-C{middle dot}DNA Complex and Its Perturbation upon Phosphorylation by Cdc2 Kinase J. Biol. Chem., January 21, 2000; 275(3): 1793 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. R. Petit, J. Fradelizi, R. M. Golsteyn, T. A.Y. Ayoubi, B. Menichi, D. Louvard, W. J. M. Van de Ven, and E. Friederich LPP, an Actin Cytoskeleton Protein Related to Zyxin, Harbors a Nuclear Export Signal and Transcriptional Activation Capacity Mol. Biol. Cell, January 1, 2000; 11(1): 117 - 129. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Klotzbucher, A. Wasserfall, and U. Fuhrmann Misexpression of Wild-Type and Truncated Isoforms of the High-Mobility Group I Proteins HMGI-C and HMGI(Y) in Uterine Leiomyomas Am. J. Pathol., November 1, 1999; 155(5): 1535 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Battista, V. Fidanza, M. Fedele, A. J. P. Klein-Szanto, E. Outwater, H. Brunner, M. Santoro, C. M. Croce, and A. Fusco The Expression of a Truncated HMGI-C Gene Induces Gigantism Associated with Lipomatosis Cancer Res., October 1, 1999; 59(19): 4793 - 4797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bustin Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins Mol. Cell. Biol., August 1, 1999; 19(8): 5237 - 5246. [Full Text] [PDF]
|
|
|
|
|
|
X. M. Zhang and G. L. Verdine A Small Region in HMG I(Y) Is Critical for Cooperation with NF-kappa B on DNA J. Biol. Chem., July 16, 1999; 274(29): 20235 - 20243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Diana, R. Sgarra, G. Manfioletti, A. Rustighi, D. Poletto, M. T. Sciortino, A. Mastino, and V. Giancotti A Link between Apoptosis and Degree of Phosphorylation of High Mobility Group A1a Protein in Leukemic Cells J. Biol. Chem., March 30, 2001; 276(14): 11354 - 11361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Demarchi, R. Verardo, B. Varnum, C. Brancolini, and C. Schneider Gas6 Anti-apoptotic Signaling Requires NF-kappa B Activation J. Biol. Chem., August 17, 2001; 276(34): 31738 - 31744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Baldassarre, M. Fedele, S. Battista, A. Vecchione, A. J. P. Klein-Szanto, M. Santoro, T. A. Waldmann, N. Azimi, C. M. Croce, and A. Fusco Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway PNAS, July 3, 2001; 98(14): 7970 - 7975. [Abstract] [Full Text] [PDF]
|
|