Nucleic Acids Research, Vol 26, Issue 7 1551-1559, Copyright © 1998 by Oxford University Press
WS Dynan and S Yoo
The Ku protein-DNA-dependent protein kinase system is one of the major
pathways by which cells of higher eukaryotes respond to double-strand DNA
breaks. The components of the system are evolutionarily conserved and
homologs are known from a number of organisms. The Ku protein component
binds directly to DNA ends and may help align them for ligation. Binding of
Ku protein to DNA also nucleates formation of an active enzyme complex
containing the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
The interaction between Ku protein, DNA- PKcs and nucleic acids has been
extensively investigated. This review summarizes the results of these
biochemical investigations and relates them to recent molecular genetic
studies that reveal highly characteristic repair and recombination defects
in mutant cells lacking Ku protein or DNA-PKcs.
REVIEWS
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
Program in Gene Regulation, Institute of Molecular Medicine and Genetics, Room CB-2803, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA. dynan@immag.mcg.edu
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S. A. Nick McElhinny, C. M. Snowden, J. McCarville, and D. A. Ramsden Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends Mol. Cell. Biol., May 1, 2000; 20(9): 2996 - 3003. [Abstract] [Full Text]
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J. Guan, S. DiBiase, and G. Iliakis The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication Nucleic Acids Res., March 1, 2000; 28(5): 1183 - 1192. [Abstract] [Full Text] [PDF]
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S. J. DiBiase, Z.-C. Zeng, R. Chen, T. Hyslop, W. J. Curran Jr., and G. Iliakis DNA-dependent Protein Kinase Stimulates an Independently Active, Nonhomologous, End-Joining Apparatus Cancer Res., March 1, 2000; 60(5): 1245 - 1253. [Abstract] [Full Text]
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A. J. R. Bishop, C. Barlow, A. J. Wynshaw-Boris, and R. H. Schiestl Atm Deficiency Causes an Increased Frequency of Intrachromosomal Homologous Recombination in Mice Cancer Res., January 1, 2000; 60(2): 395 - 399. [Abstract] [Full Text]
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S. Majumder, K. Ghoshal, Z. Li, and S. T. Jacob Hypermethylation of Metallothionein-I Promoter and Suppression of Its Induction in Cell Lines Overexpressing the Large Subunit of Ku Protein J. Biol. Chem., October 1, 1999; 274(40): 28584 - 28589. [Abstract] [Full Text] [PDF]
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J. A. Downs and S. P. Jackson Involvement of DNA End-Binding Protein Ku in Ty Element Retrotransposition Mol. Cell. Biol., September 1, 1999; 19(9): 6260 - 6268. [Abstract] [Full Text] [PDF]
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S. Yoo, A. Kimzey, and W. S. Dynan Photocross-linking of an Oriented DNA Repair Complex. Ku BOUND AT A SINGLE DNA END J. Biol. Chem., July 9, 1999; 274(28): 20034 - 20039. [Abstract] [Full Text] [PDF]
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P. E. Shockett and D. G. Schatz DNA Hairpin Opening Mediated by the RAG1 and RAG2 Proteins Mol. Cell. Biol., June 1, 1999; 19(6): 4159 - 4166. [Abstract] [Full Text] [PDF]
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A. Nueda, F. Hudson, N. F. Mivechi, and W. S. Dynan DNA-dependent Protein Kinase Protects against Heat-induced Apoptosis J. Biol. Chem., May 21, 1999; 274(21): 14988 - 14996. [Abstract] [Full Text] [PDF]
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B. K. Singleton, M. I. Torres-Arzayus, S. T. Rottinghaus, G. E. Taccioli, and P. A. Jeggo The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit Mol. Cell. Biol., May 1, 1999; 19(5): 3267 - 3277. [Abstract] [Full Text] [PDF]
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G. C.M. Smith and S. P. Jackson The DNA-dependent protein kinase Genes & Dev., April 15, 1999; 13(8): 916 - 934. [Full Text]
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P. Labhart Ku-Dependent Nonhomologous DNA End Joining in Xenopus Egg Extracts Mol. Cell. Biol., April 1, 1999; 19(4): 2585 - 2593. [Abstract] [Full Text] [PDF]
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R. L. Woodard, M. G. Anderson, and W. S. Dynan Nuclear Extracts Lacking DNA-dependent Protein Kinase Are Deficient in Multiple Round Transcription J. Biol. Chem., January 1, 1999; 274(1): 478 - 485. [Abstract] [Full Text] [PDF]
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M. A. Bogue, C. Jhappan, and D. B. Roth Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation PNAS, December 22, 1998; 95(26): 15559 - 15564. [Abstract] [Full Text] [PDF]
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M. Giampuzzi, G. Botti, M. Di Duca, L. Arata, G. Ghiggeri, R. Gusmano, R. Ravazzolo, and A. Di Donato Lysyl Oxidase Activates the Transcription Activity of Human Collagene III Promoter. POSSIBLE INVOLVEMENT OF Ku ANTIGEN J. Biol. Chem., November 10, 2000; 275(46): 36341 - 36349. [Abstract] [Full Text] [PDF]
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K.-J. Lee, J. Huang, Y. Takeda, and W. S. Dynan DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System J. Biol. Chem., October 27, 2000; 275(44): 34787 - 34796. [Abstract] [Full Text] [PDF]
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L. Uliel, P. Weisman-Shomer, H. Oren-Jazan, T. Newcomb, L. A. Loeb, and M. Fry Human Ku Antigen Tightly Binds and Stabilizes a Tetrahelical Form of the Fragile X Syndrome d(CGG)n Expanded Sequence J. Biol. Chem., October 13, 2000; 275(42): 33134 - 33141. [Abstract] [Full Text] [PDF]
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B. Li and L. Comai Requirements for the Nucleolytic Processing of DNA Ends by the Werner Syndrome Protein-Ku70/80 Complex J. Biol. Chem., March 23, 2001; 276(13): 9896 - 9902. [Abstract] [Full Text] [PDF]
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R. L. Woodard, K.-j. Lee, J. Huang, and W. S. Dynan Distinct Roles for Ku Protein in Transcriptional Reinitiation and DNA Repair J. Biol. Chem., April 27, 2001; 276(18): 15423 - 15433. [Abstract] [Full Text] [PDF]
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