Nucleic Acids Research, Vol 27, Issue 1 268-271, Copyright © 1999 by Oxford University Press
IA Adzhubei and AA Adzhubei
Two more organisms from different taxonomic groups were added to a new
version of the Integrated Sequence-Structure Database (ISSD). ISSD serves
as an integrated source of sequence and structure information for the
analysis of correlations between mRNA synonymous codon usage and
three-dimensional structure of the encoded proteins. ISSD now holds 88
non-homologous Escherichia coli proteins and 25 yeast Saccharomyces
cerevisiae proteins in addition to the expanded set of mammalian proteins,
which includes 166 proteins (107 in ISSD Version 1.0). Comparison of ISSD
sequences with organism-specific codon usage data derived from CUTG
database shows that it is a representative subset of the GenBank coding
sequences data. Preliminary results of the statistical analysis confirm
that sequence-structure correlations observed by us earlier are also
present in the upgraded ISSD (Version 2.0), including bacterial and yeast
proteins. The ISSD Version 2.0 release includes an improved Web-based data
search and retrieval system and is accessible via URL
http://www.protein.bio.msu.su/issd/. ISSD can be also accessed at ExPASy,
URL http://www.expasy.ch/swissmod/swiss- model.htm l
ARTICLES
ISSD Version 2.0: taxonomic range extended
Department of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, 119899 Moscow, Russia.
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