Nucleic Acids Research, Vol 27, Issue 1 29-34, Copyright © 1999 by Oxford University Press
H Ogata, S Goto, K Sato, W Fujibuchi, H Bono and M Kanehisa
Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for
systematic analysis of gene functions in terms of the networks of genes and
molecules. The major component of KEGG is the PATHWAY database that
consists of graphical diagrams of biochemical pathways including most of
the known metabolic pathways and some of the known regulatory pathways. The
pathway information is also represented by the ortholog group tables
summarizing orthologous and paralogous gene groups among different
organisms. KEGG maintains the GENES database for the gene catalogs of all
organisms with complete genomes and selected organisms with partial
genomes, which are continuously re-annotated, as well as the LIGAND
database for chemical compounds and enzymes. Each gene catalog is
associated with the graphical genome map for chromosomal locations that is
represented by Java applet. In addition to the data collection efforts,
KEGG develops and provides various computational tools, such as for
reconstructing biochemical pathways from the complete genome sequence and
for predicting gene regulatory networks from the gene expression profiles.
The KEGG databases are daily updated and made freely available
(http://www.genome.ad.jp/kegg/).
ARTICLES
KEGG: Kyoto Encyclopedia of Genes and Genomes
Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
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