Nucleic Acids Research, Vol 27, Issue 1 340-342, Copyright © 1999 by Oxford University Press
N Le Novere and JP Changeux
The ligand gated ion channels (LGICs) are ionotropic receptors to
neurotransmitters. Their physiological effect is carried out by the opening
of an ionic channel upon binding of a particular neurotransmitter. These
LGICs constitute superfamilies of receptors formed by homologous subunits.
A database has been developed to handle the growing wealth of cloned
subunits. This database contains nucleic acid sequences, protein sequences,
as well as multiple sequence alignments and phylogenetic studies. This
database is accessible via the worldwide web
(http://www.pasteur.fr/units/neubiomol/LGIC.h tml), where it is
continuously updated. A downloadable version is also available [currently
v0.1 (98.06)].
ARTICLES
The Ligand Gated Ion Channel Database
Neurobiologie Moleculaire, URA CNRS 1281, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France. lenov@pasteur.fr
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