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Nucleic Acids Research, Vol 27, Issue 10 2086-2090, Copyright © 1999 by Oxford University Press

ARTICLES

Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

YZ Liu, LM Boxer and DS Latchman
Department of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London,The Windeyer Building, Cleveland Street, London W1P 6DB, UK.

The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.
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