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Nucleic Acids Research, Vol 27, Issue 15 3035-3041, Copyright © 1999 by Oxford University Press

ARTICLES

Oligonucleotide dendrimers: stable nano-structures

MS Shchepinov, KU Mir, JK Elder, MD Frank-Kamenetskii and EM Southern
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK and. misha@bioch.ox.ac.uk

DNA dendrimers with two, three, six, nine or 27 arms were reassociated as complementary pairs in solution or with an array of complementary oligonucleotides on a solid support. In all cases, duplex stabilities were greater than those of unbranched molecules of equal length. A theoretical treatment for the process of dissociation of dendrimers explains the major properties of the complexes. The favourable features of DNA dendrimers-their enhanced stability and the simple predictability of their association behaviour-makes them promising as building blocks for the 'bottom up' approach to nano-assembly. These features also suggest applications in oligonucleotide array/DNA chip technology when higher hybridisation temperatures are required, for example, to melt secon-dary structure in the target.
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