Nucleic Acids Research, Vol 27, Issue 16 3318-3324, Copyright © 1999 by Oxford University Press
M Agudo, A Losada, JP Abad, S Pimpinelli, P Ripoll and A Villasante
Cytological and cytogenetic studies have previously defined the region
needed for centromeric function in the Y chromosome of Drosophila
melanogaster. We have identified a YAC clone that originated from this
region. Molecular analysis of the YAC and genomic DNAs has allowed the
description of a satellite DNA made of telomeric HeT-A- and TART- derived
sequences and the construction of a long-range physical map of the
heterochromatic region h18. Sequences within the YAC clone are conserved in
the centromeric region of the sibling species Drosophila simulans. That
telomere-derived DNA now forms part of the centromeric region of the Y
chromosome could indicate a telomeric origin of this centromere. The
existence of common determinants for the function of both centromeres and
telomeres is discussed.
ARTICLES
Centromeres from telomeres? The centromeric region of the Y chromosome of Drosophila melanogaster contains a tandem array of telomeric HeT-A- and TART-related sequences
Centro de Biologia Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
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