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Nucleic Acids Research, Vol 27, Issue 17 3493-3493, Copyright © 1999 by Oxford University Press

ARTICLES

DNAPROBE, a computer program which generates oligonucleotide probes from protein alignments

M Drummond and J Stamper
Nitrogen Fixation Laboratory, John Innes Institute, Colney Lane, Norwich NR4 7UH, UK. martin.drummond@bbsrc.ac.ui

We describe a program to assist in designing oligonucleotide probes on the basis of protein alignments and the codon usage of the target organism. If necessary, the input sequences can be weighted to neutralise the effect of closely similar sequences or to bias the output in favour of a particular taxon.
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