Nucleic Acids Research, Vol 27, Issue 21 4191-4199, Copyright © 1999 by Oxford University Press
C Park, MJ Lecomte and C Schindler
Characterization of the ability of human interferons (IFNs) to rapidly
induce genes led to the identification of the first two members of the STAT
(signal transducers and activators of transcription) family, Stat1 and
Stat2. To study the unique role of this transcription factor in IFN
signaling under more physiological conditions, murine Stat2 was isolated
and found to be surprisingly divergent. This divergence was most striking
in the C-terminal transcriptional activation domain. Studies on murine
Stat2 indicate that it functions in IFN signaling. This includes
IFN-alpha-dependent activation, nuclear translocation, DNA binding and
activation of reporter genes. However, the profound divergence at the
C-terminus suggests that murine Stat2 may have evolved to mediate some
unique functions as well. To explore this possibility, proteins that
interact with the C-termini of murine and human Stat2 were examined. These
studies indicate that the murine and human C-termini interact with an
overlapping, but distinct set of proteins.
ARTICLES
Murine Stat2 is uncharacteristically divergent
Departments of Microbiology and Medicine, Columbia University, HHSC- 1212, 701 West 168th Street, New York, NY 10032, USA.
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