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Nucleic Acids Research, Vol 27, Issue 8 1854-1858, Copyright © 1999 by Oxford University Press

ARTICLES

Damage increases the flexibility of duplex DNA

VM Marathias, B Jerkovic and PH Bolton
Chemistry Department, Wesleyan University, Middletown, CT 06459, USA.

It is proposed that much of the recognition of specific types of damaged DNAs is based on accessible structural features, while much of the recognition of damaged DNAs, as a class, is based on flexibility. The more flexible a DNA the faster its diffusion rate. The diffusion rates of each member of a series of damaged duplex DNAs has been found to be significantly faster than that of the corresponding undamaged duplex DNA. The damaged sites studied include apurinic and apyrimidinic a basic sites, thymine glycol and urea. The presence of mismatched sites also increases the diffusion. Thus, damaged DNAs appear to have sufficient flexibility for recognition and the flexibility may allow damaged sites to act as a universal joint or hinge that allows distant sites on the DNA to come together.
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