Nucleic Acids Research, 2000, Vol. 28, No. 1 148-152
© 2000 Oxford University Press
MitBASE : a comprehensive and integrated mitochondrial DNA database. The present status
Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Bari, 70126 Bari, Italy, 1Centro di Studio sui Mitocondri e Metabolismo Energetico, CNR, 70126 Bari, Italy, 2Vakgroep Biochemie, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands, 3Ulm University, D-89069 Ulm, Germany, 4Department of Clinical Neurosciences, Royal Free Hospital, London, UK, 5Area di Ricerca, CNR, 70126 Bari, Italy, 6Departamento de Biología Molecular, Hospital Universitario ‘Marqués de Valdecilla’, Universidad de Cantabria, 39011 Santander, Spain, 7Centre de Genetique Moleculaire, CNRS, 91198 Gif-sur-Yvette, France, 8EBI Hinxton Hall, Hinxton, Cambridge, UK and 9Department of Clinical Neurology, Institute of Neurology, London, UK
MitBASE is an integrated and comprehensive database of mitochondrial DNA data which collects, under a single interface, databases for Plant, Vertebrate, Invertebrate, Human, Protist and Fungal mtDNA and a Pilot database on nuclear genes involved in mitochondrial biogenesis in Saccharomyces cerevisiae. MitBASE reports all available information from different organisms and from intraspecies variants and mutants. Data have been drawn from the primary databases and from the literature; value adding information has been structured, e.g., editing information on protist mtDNA genomes, pathological information for human mtDNA variants, etc. The different databases, some of which are structured using commercial packages (Microsoft Access, File Maker Pro) while others use a flat-file format, have been integrated under ORACLE. Ad hoc retrieval systems have been devised for some of the above listed databases keeping into account their peculiarities. The database is resident at the EBI and is available at the following site: http://www3.ebi.ac.uk/Research/Mitbase/mitbase.pl . The impact of this project is intended for both basic and applied research. The study of mitochondrial genetic diseases and mitochondrial DNA intraspecies diversity are key topics in several biotechnological fields. The database has been funded within the EU Biotechnology programme.
* To whom correspondence should be addressed. Tel: +39 080 548 2130; Fax: +39 080 548 4467; Email: marcella@area.ba.cnr.it
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