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Nucleic Acids Research, 2000, Vol. 28, No. 1 270-272
© 2000 Oxford University Press

The SYSTERS protein sequence cluster set

A. Krause*, J. Stoye and M. Vingron

Deutsches Krebsforschungszentrum, Theoretische Bioinformatik, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

The SYSTERS (short for SYSTEmatic Re-Searching) protein sequence cluster set consists of the classification of all sequences from SWISS-PROT and PIR into disjoint protein family clusters and hierarchically into superfamily and subfamily clusters. The cluster set can be searched with a sequence using the SSMAL search tool or a traditional database search tool like BLAST or FASTA. Additionally a multiple alignment is generated for each cluster and annotated with domain information from the Pfam database of protein domain families. A taxonomic overview of the organisms covered by a cluster is given based on the NCBI taxonomy. The cluster set is available for querying and browsing at http://www.dkfz-heidelberg.de/tbi/services/cluster/systersform

* To whom correspondence should be addressed. Tel: +49 6221 42 2720; Fax: +49 6221 42 2849; Email: a.krause@dkfz-heidelberg.de


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