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Nucleic Acids Research, 2000, Vol. 28, No. 1 283-285
© 2000 Oxford University Press

ProTherm, version 2.0: thermodynamic database for proteins and mutants

M. Michael Gromiha, Jianghong An, Hidetoshi Kono, Motohisa Oobatake, Hatsuho Uedaira, P. Prabakaran and Akinori Sarai*

Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan

ProTherm 2.0 is the second release of the Thermo­dynamic Database for Proteins and Mutants that includes numerical data for several thermodynamic parameters, structural information, experimental methods and conditions, functional and literature information. The present release contains >5500 entries, an ~67% increase over the previous version. In addition, we have included information about reversibility of data, details about buffer and ion concentrations and the surrounding residues in space for all mutants. A WWW interface enables users to search data based on various conditions with different sorting options for outputs. Further, ProTherm has links with other structural and literature databases, and the mutation sites and surrounding residues are automatically mapped on the structures and can be directly viewed through 3DinSight developed in our laboratory. The ProTherm database is freely available through the WWW at http://www.rtc.riken.go.jp/protherm.html

* To whom correspondence should be addressed. Tel: +81 298 36 9082; Fax: +81 298 36 9080; Email: sarai@rtc.riken.go.jp Present addresses: Hidetoshi Kono, Department of Chemistry, Pennsylvania University, 231S 34 Street, PA 19104, USA Motohisa Oobatake, Faculty of Science and Technology, Meijo University, 1-501 Shiogamaguchi, Tenpaku-ku, Nagoya 468-8502, Japan


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