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Nucleic Acids Research, 2000, Vol. 28, No. 1 337-340
© 2000 Oxford University Press

HOX Pro: a specialized database for clusters and networks of homeobox genes

Alexander V. Spirov, Timothy Bowler1,* and John Reinitz1

The Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Thorez Avenue, St Petersburg 194223, Russia and 1Department of Biochemistry and Molecular Biology, Box 1020, Mt Sinai Medical School, One Gustave L. Levy Place, New York, NY 10029, USA

It is now clear that the homeobox motif is well conserved across metazoan phyla. It has been established experimentally that a subset of genes containing this motif plays key roles in the orchestration of gene expression during development. Auto- and cross-regulatory functional interactions join homeobox genes into genetic networks. We have developed a specialized database HOX-Pro in order to arrange all available data on structure, function, phylogeny and evolution of Hox genes, Hox clusters and Hox networks. Its primary location is http://www.iephb.nw.ru/hoxpro . The database is also mirrored at http://www.mssm.edu/molbio/hoxpro . The HOX-Pro database is aimed at: (i) analysis and classification of regulatory and coding regions in diverse homeobox and related genes; (ii) comparative analysis of organization of ‘Hox-based’ genetic networks in the sea urchin Strongylocentrotus purpuratus, the fruit fly Drosophila melanogaster and the mouse Mus musculus; and (iii) analysis of phylo­geny and evolution of homeobox genes and clusters.

* To whom correspondence should be addressed. Tel: +1 212 241 6782; Fax: +1 212 860 9279; Email: tgb@eve.molbio.mssm.edu


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