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Nucleic Acids Research, 2000, Vol. 28, No. 1 65-67
© 2000 Oxford University Press

RegulonDB (version 3.0): transcriptional regulation and operon organization in Escherichia coli K-12

Heladia Salgado, Alberto Santos-Zavaleta, Socorro Gama-Castro, Dulce Millán-Zárate, Frederick R. Blattner1 and Julio Collado-Vides*

Centro de Investigación sobre Fijación de Nitrógeno, UNAM A.P. 565-A Cuernavaca, Morelos 62100, México and 1Department of Genetics, University of Wisconsin, Madison, 445 Henry Mall Madison, WI 53706, USA

RegulonDB is a database on transcription regulation and operon organization in Escherichia coli. The current version describes regulatory signals of transcription initiation, promoters, regulatory binding sites of specific regulators, ribosome binding sites and terminators, as well as information on genes clustered in operons. These specific annotations have been gathered from a constant search in the literature, as well as based on computational sequence predictions. The genomic coordinates of all these objects in the E.coli K-12 chromosome are clearly indicated. Every known object has a link to at least one MEDLINE reference. We have also added direct links to recent expression data of E.coli K-12. The version presented here has important modifications both in the structure of the database, as well as in the amount and type of information encoded in the database. RegulonDB can be accessed on the web at URL: http://www.cifn.unam.mx/Computational_Biology/regulondb/

* To whom correspondence should be addressed. Tel: +527 313 2063; Fax: +527 317 5581; Email: ecoli-t1@cifn.unam.mx


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