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Nucleic Acids Research, 2000, Vol. 28, No. 12 2311-2314
© 2000 Oxford University Press

Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA

Mutsunori Shirai*, Hideki Hirakawa1, Mitsuaki Kimoto, Mitsuaki Tabuchi2, Fumio Kishi2, Kazunobu Ouchi3, Tadayoshi Shiba4, Kazuo Ishii5, Masahira Hattori5, Satoru Kuhara1 and Teruko Nakazawa

Department of Microbiology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan, 1Graduate School of Genetic Resources Technology, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan, 2Center for Gene Research, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan, 3Shimonoseki Saiseikai General Hospital, Kifune-cho, Shimonoseki, Yamaguchi 750-0823, Japan, 4Kitasato University School of Science and 5RIKEN Genomic Sciences Center, Sagamihara, Kanagawa 228-8555, Japan

Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C.pneumoniae infection and atherosclerosis. We determined the whole genome sequence of C.pneumoniae strain J138 isolated in Japan in 1994 and compared it with the sequence of strain CWL029 isolated in the USA before 1987. The J138 circular chromosome consists of 1 226 565 nt (40.7% G+C) with 1072 likely protein-coding genes that is 3665 nt shorter than the CWL029 genome. Plasmids, phage- or transposon-like sequences were not identified. The overall genomic organization, gene order and predicted proteomes of the two strains are very similar, suggesting a high level of structural and functional conservation between the two unrelated isolates. The most conspicuous differences in the J138 genome relative to the CWL029 genome are the absence of five DNA segments, ranging in size from 89 to 1649 nt, and the presence of three DNA segments, ranging from 27 to 84 nt. The complex organization of these ‘different zones’ may be attributable to a unique system of recombination.

* To whom correspondence should be addressed. Tel: +81 836 22 2227; Fax +81 836 22 2415; Email: mshirai@po.cc.yamaguchi-u.ac.jp


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