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Nucleic Acids Research, 2000, Vol. 28, No. 15 2855-2861
© 2000 Oxford University Press

The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA

David A. Dunbar1, Andrew A. Chen1, Steven Wormsley1 and Susan J. Baserga1,2,*

1Department of Therapeutic Radiology and 2Department of Genetics, Yale School of Medicine, 333 Cedar Street, PO Box 208040, New Haven, CT 06520-8040, USA

Because the organization of snoRNA genes in vertebrates, plants and yeast is diverse, we investigated the organization of snoRNA genes in a distantly related organism, Trypanosoma brucei. We have characterized the second example of a snoRNA gene cluster that is tandemly repeated in the T.brucei genome. The genes encoding the box C/D snoRNAs TBR12, TBR6, TBR4 and TBR2 make up the cluster. In a genomic organization unique to trypanosomes, there are at least four clusters of these four snoRNA genes tandemly repeated in the T.brucei genome. We show for the first time that the genes encoding snoRNAs in both this cluster and the SLA cluster are transcribed in an unusual way as a polycistronic RNA.

* To whom correspondence should be addressed at: Department of Therapeutic Radiology, HRT 317, Yale School of Medicine, New Haven, CT 06520-8040, USA. Tel: +1 203 785 4618; Fax: +1 203 785 6309; Email: susan.baserga@yale.edu


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