Nucleic Acids Research, 2000, Vol. 28, No. 16 3011-3016
© 2000 Oxford University Press
SURVEY AND SUMMARY
From DNA biosensors to gene chips
Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA
Wide-scale DNA testing requires the development of small, fast and easy-to-use devices. This article describes the preparation, operation and applications of biosensors and gene chips, which provide fast, sensitive and selective detection of DNA hybridization. Various new strategies for DNA biosensors and gene chips are examined, along with recent trends and future directions. The integration of hybridization detection schemes with the sample preparation process in a ‘Lab-on-a-Chip’ format is also covered. While the use of DNA biosensors and gene chips is at an early stage, such devices are expected to have an enormous effect on future DNA diagnostics.
* Tel: +1 505 646 2140; Fax: +1 505 646 6033; Email: joewang@nmsu.edu
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