Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (919K) Freely available
Right arrow Supplementary Data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Stanford, D. R.
Right arrow Articles by Hopper, A. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stanford, D. R.
Right arrow Articles by Hopper, A. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2000, Vol. 28, No. 2 383-392
© 2000 Oxford University Press

SURVEY AND SUMMARY: ADEPTs: information necessary for subcellular distribution of eukaryotic sorting isozymes resides in domains missing from eubacterial and archaeal counterparts

David R. Stanford, Nancy C. Martin1 and Anita K. Hopper*

Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, H171, 500 University Drive, Hershey, PA 17033, USA and 1Department of Biochemistry, University of Louisville School of Medicine, 312 Abraham Flexner Way, Louisville, KY 40292, USA

Sorting isozymes are encoded by single genes, but the encoded proteins are distributed to multiple subcellular compartments. We surveyed the predicted protein sequences of several nucleic acid interacting sorting isozymes from the eukaryotic taxonomic domain and compared them with their homologs in the archaeal and eubacterial domains. Here, we summarize the data showing that the eukaryotic sorting isozymes often possess sequences not present in the archaeal and eubacterial counterparts and that the additional sequences can act to target the eukaryotic proteins to their appropriate subcellular locations. Therefore, we have named these protein domains ADEPTs (Additional Domains for Eukaryotic Protein Targeting). Identification of additional domains by phylogenetic comparisons should be generally useful for locating candidate sequences important for subcellular distribution of eukaryotic proteins.

* To whom correspondence should be addressed. Tel: +1 717 531 6008; Fax: +1 717 531 7072; Email: ahopper@psu.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
M. Nakao, R. A. Barrero, Y. Mukai, C. Motono, M. Suwa, and K. Nakai
Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals
Nucleic Acids Res., April 28, 2005; 33(8): 2355 - 2363.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Lemieux, B. Lakowski, A. Webb, Y. Meng, A. Ubach, F. Bussiere, T. Barnes, and S. Hekimi
Regulation of Physiological Rates in Caenorhabditis elegans by a tRNA-Modifying Enzyme in the Mitochondria
Genetics, September 1, 2001; 159(1): 147 - 157.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. K. Azad, D. R. Stanford, S. Sarkar, and A. K. Hopper
Role of Nuclear Pools of Aminoacyl-tRNA Synthetases in tRNA Nuclear Export
Mol. Biol. Cell, May 1, 2001; 12(5): 1381 - 1392.
[Abstract] [Full Text]

Home page
 Nucleic Acids ResHome page
M. L. Engel, J. C. Hines, and D. S. Ray
The Crithidia fasciculata RNH1 gene encodes both nuclear and mitochondrial isoforms of RNase H
Nucleic Acids Res., February 1, 2001; 29(3): 725 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Liu and K. B. Straby
The human tRNA(m22G26)dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene
Nucleic Acids Res., September 15, 2000; 28(18): 3445 - 3451.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.