Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (310K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Takanami, T.
Right arrow Articles by Higashitani, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takanami, T.
Right arrow Articles by Higashitani, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2000, Vol. 28, No. 21 4232-4236
© 2000 Oxford University Press

Hyper-resistance of meiotic cells to radiation due to a strong expression of a single recA-like gene in Caenorhabditis elegans

Takako Takanami, Akiyuki Mori, Hideyuki Takahashi and Atsushi Higashitani*

Institute of Genetic Ecology, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan

Sensitivity of meiotic cells to DNA damaging agents is little understood. We have demonstrated that the meiotic pachytene nuclei in the Caenorhabditis elegans gonad are hyper-resistant to X-ray irradiation, but not to UV irradiation, whereas the early embryonic cells after fertilization and the full grown oocytes are not. The Ce-rdh-1 gene [RAD51, DMC1 (LIM15), homolog 1 or Ce-rad-51], which is essential for the meiotic recombination, is the only bacterial recA-like gene in the nematode genome, and is strongly expressed in the meiotic cells. Following silencing of the Ce-rdh-1 gene by RNA interference, the meiotic cells become more sensitive to X-ray irradiation than the early embryonic cells. This is the first report that meiotic cells are hyper-resistant to DNA strand breaks due to the high level of expression of the enzyme(s) involved in meiotic homologous recombination.

* To whom correspondence should be addressed. Tel: +81 22 217 5715; Fax: +81 22 723 8218; Email: ahigashi@ige.tohoku.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
J. Luo, S. Shah, K. Riabowol, and P. E. Mains
The Caenorhabditis elegans ing-3 Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway
Genetics, February 1, 2009; 181(2): 473 - 482.
[Abstract] [Full Text] [PDF]

Home page
 DNA ResHome page
T. Eki, T. Ishihara, I. Katsura, and F. Hanaoka
A Genome-wide Survey and Systematic RNAi-based Characterization of Helicase-like Genes in Caenorhabditis elegans
DNA Res, October 6, 2007; (2007) dsm016v1.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Nakamura, R. Ando, T. Nakazawa, T. Yudazono, N. Tsutsumi, N. Hatanaka, T. Ohgake, F. Hanaoka, and T. Eki
Dicer-related drh-3 gene functions in germ-line development by maintenance of chromosomal integrity in Caenorhabditis elegans
Genes Cells, September 1, 2007; 12(9): 997 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
F. W. Stahl, H. M. Foss, L. S. Young, R. H. Borts, M. F. F. Abdullah, and G. P. Copenhaver
Does Crossover Interference Count in Saccharomyces cerevisiae?
Genetics, September 1, 2004; 168(1): 35 - 48.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. Rinaldo, P. Bazzicalupo, S. Ederle, M. Hilliard, and A. La Volpe
Roles for Caenorhabditis elegans rad-51 in Meiosis and in Resistance to Ionizing Radiation During Development
Genetics, February 1, 2002; 160(2): 471 - 479.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. N. Khodarev, J. O. Park, J. Yu, N. Gupta, E. Nodzenski, B. Roizman, and R. R. Weichselbaum
Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts
PNAS, October 23, 2001; 98(22): 12665 - 12670.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.