Nucleic Acids Research, 2000, Vol. 28, No. 3 663-668
© 2000 Oxford University Press
SURVEY AND SUMMARY A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter
AIDS Molecular Biology Unit, National Centre for HIV Virology Research, The Macfarlane Burnet Centre for Medical Research, PO Box 254, Fairfield, Victoria 3078, Australia
The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. To date a large number of sequence-specific DNA–protein interactions have been described for the HIV-1 LTR. The aim of this report is to provide a comprehensive, updated listing of these HIV-1 LTR interactions. It is intended as a reference point to facilitate on-going studies characterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replication.
* To whom correspondence should be addressed. Tel: +61 3 9282 2234; Fax: +61 3 9482 6152; Email: deacon@burnet.edu.au Present addresses: Lloyd A. Pereira, Laboratory for Physiological Chemistry, Utrecht University, Universiteitsweg 100, 3584G CG Utrecht, The Netherlands Anna Peeters, Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia
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