Nucleic Acids Research, 2000, Vol. 28, No. 6 1283-1298
© 2000 Oxford University Press
SURVEY AND SUMMARY Transcription by RNA polymerases I and III
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA and 1Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK
The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesises the large rRNA, pol II synthesises mRNA and pol III synthesises tRNA and 5S rRNA. Although pol II has received most attention, pol I and pol III are together responsible for the bulk of transcriptional activity. This survey will summarise what is known about the process of transcription by pol I and pol III, how it happens and the proteins involved. Attention will be drawn to the similarities between the three nuclear RNA polymerase systems and also to their differences.
* To whom correspondence should be addressed. Tel: +44 141 330 4628; Fax: +44 141 330 4620; Email: rwhite@udcf.gla.ac.uk Correspondence may also be addressed to M.R.P: Tel: +1 970 491 6748; Fax: +1 970 491 0494; Email: mpaule@lamar.colostate.edu
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|
|
|
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|
|
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|
|
|
|
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|
|
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|
|
|
|
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|
|
|
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|
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|
|
|
|
|
|
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|
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|
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|
|
|
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