Nucleic Acids Research, 2001, Vol. 29, No. 1 246-254
© 2001 Oxford University Press
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins
Department of Biostatistics, Epidemiology and Scientific Computing (Bioinformatics Section) and 1Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia and 2Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
The adenylate uridylate-rich elements (AREs) mediate the rapid turnover of mRNAs encoding proteins that regulate cellular growth and body response to exogenous agents such as microbes, inflammatory and environmental stimuli. However, the full repertoire of ARE-containing mRNAs is unknown. Here, we explore the distribution of AREs in human mRNA sequences. Computational derivation of a 13-bp ARE pattern was performed using multiple expectation maximization for motif elicitations (MEME) and consensus analyses. This pattern was statistically validated for the specificity towards the 3'-untranslated region and not coding region. The computationally derived ARE pattern is the basis of a database which contains non-redundant full-length ARE-mRNAs. The ARE-mRNA database (ARED; http://rc.kfshrc.edu.sa/ared) reveals that ARE-mRNAs encode a wide repertoire of functionally diverse proteins that belong to different biological processes and are important in several disease states. Cluster analysis was performed using the ARE sequences to demonstrate potential relationships between the type and number of ARE motifs, and the functional characteristics of the proteins.
* To whom correspondence should be addressed at: Head, Interferon and Cytokine Research Unit (MBC-03), Senior Scientist, Department of Biological and Medical Research, PO Box 3354, MBC-03, Riyadh 11211, Saudi Arabia. Tel: +966 1 442 7876; Fax: +966 1 442 7858; Email: khabar{at}kfshrc.edu.sa
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Zhang, T. Zou, J. N. Rao, L. Liu, L. Xiao, P.-Y. Wang, Y.-H. Cui, M. Gorospe, and J.-Y. Wang Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines Nucleic Acids Res., October 13, 2009; (2009) gkp755v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Trojanowicz, L. Brodauf, C. Sekulla, K. Lorenz, R. Finke, H. Dralle, and C. Hoang-Vu The role of AUF1 in thyroid carcinoma progression Endocr. Relat. Cancer, September 1, 2009; 16(3): 857 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Laloo, D. Simon, V. Veillat, D. Lauzel, V. Guyonnet-Duperat, F. Moreau-Gaudry, F. Sagliocco, and C. Grosset Analysis of Post-transcriptional Regulations by a Functional, Integrated, and Quantitative Method Mol. Cell. Proteomics, August 1, 2009; 8(8): 1777 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Al-Ahmadi, M. Al-Ghamdi, L. Al-Haj, M. Al-Saif, and K. S. A. Khabar Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation Nucleic Acids Res., June 1, 2009; 37(11): 3612 - 3624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cairrao, A. S. Halees, K. S. A. Khabar, D. Morello, and N. Vanzo AU-Rich Elements Regulate Drosophila Gene Expression Mol. Cell. Biol., May 15, 2009; 29(10): 2636 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Ogilvie, J. R. SternJohn, B. Rattenbacher, I. A. Vlasova, D. A. Williams, H. H. Hau, P. J. Blackshear, and P. R. Bohjanen Tristetraprolin Mediates Interferon-{gamma} mRNA Decay J. Biol. Chem., April 24, 2009; 284(17): 11216 - 11223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Duan, N. Cherradi, J.-J. Feige, and C. Jefcoate cAMP-Dependent Posttranscriptional Regulation of Steroidogenic Acute Regulatory (STAR) Protein by the Zinc Finger Protein ZFP36L1/TIS11b Mol. Endocrinol., April 1, 2009; 23(4): 497 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zrioual, R. Ecochard, A. Tournadre, V. Lenief, M.-A. Cazalis, and P. Miossec Genome-Wide Comparison between IL-17A- and IL-17F-Induced Effects in Human Rheumatoid Arthritis Synoviocytes J. Immunol., March 1, 2009; 182(5): 3112 - 3120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Sharova, A. A. Sharov, T. Nedorezov, Y. Piao, N. Shaik, and M. S.H. Ko Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells DNA Res, February 1, 2009; 16(1): 45 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Saunus, J. D. French, S. L. Edwards, D. J. Beveridge, E. C. Hatchell, S. A. Wagner, S. R. Stein, A. Davidson, K. J. Simpson, G. D. Francis, et al. Posttranscriptional Regulation of the Breast Cancer Susceptibility Gene BRCA1 by the RNA Binding Protein HuR Cancer Res., November 15, 2008; 68(22): 9469 - 9478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Kanies, J. J. Smith, C. Kis, C. Schmidt, S. Levy, K. S.A. Khabar, J. Morrow, N. Deane, D. A. Dixon, and R. D. Beauchamp Oncogenic Ras and Transforming Growth Factor-{beta} Synergistically Regulate AU-Rich Element-Containing mRNAs during Epithelial to Mesenchymal Transition Mol. Cancer Res., July 1, 2008; 6(7): 1124 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Calin, A. Cimmino, M. Fabbri, M. Ferracin, S. E. Wojcik, M. Shimizu, C. Taccioli, N. Zanesi, R. Garzon, R. I. Aqeilan, et al. MiR-15a and miR-16-1 cluster functions in human leukemia PNAS, April 1, 2008; 105(13): 5166 - 5171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Suswam, Y. Li, X. Zhang, G. Y. Gillespie, X. Li, J. J. Shacka, L. Lu, L. Zheng, and P. H. King Tristetraprolin Down-regulates Interleukin-8 and Vascular Endothelial Growth Factor in Malignant Glioma Cells Cancer Res., February 1, 2008; 68(3): 674 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Halees, R. El-Badrawi, and K. S. A. Khabar ARED Organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse Nucleic Acids Res., January 11, 2008; 36(suppl_1): D137 - D140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Guo, J. Ma, J. Sun, and G. Gao The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA PNAS, January 2, 2007; 104(1): 151 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wagoner, M. Austin, J. Green, T. Imaizumi, A. Casola, A. Brasier, K. S. A. Khabar, T. Wakita, M. Gale Jr., and S. J. Polyak Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection J. Virol., January 1, 2007; 81(1): 309 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Lai, J. S. Parker, S. F. Grissom, D. J. Stumpo, and P. J. Blackshear Novel mRNA Targets for Tristetraprolin (TTP) Identified by Global Analysis of Stabilized Transcripts in TTP-Deficient Fibroblasts Mol. Cell. Biol., December 15, 2006; 26(24): 9196 - 9208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Benjamin, M. Schmidlin, L. Min, B. Gross, and C. Moroni BRF1 Protein Turnover and mRNA Decay Activity Are Regulated by Protein Kinase B at the Same Phosphorylation Sites Mol. Cell. Biol., December 15, 2006; 26(24): 9497 - 9507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-Y. Lin, Y.-H. Chen, Y.-W. Lin, J.-S. Tsai, J.-W. Chen, H.-J. Wang, Y.-L. Chen, C.-Y. Li, and S.-J. Lin The Role of Human Antigen R, an RNA-binding Protein, in Mediating the Stabilization of Toll-Like Receptor 4 mRNA Induced by Endotoxin: A Novel Mechanism Involved in Vascular Inflammation Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2622 - 2629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fawal, F. Armstrong, S. Ollier, H. Dupont, C. Touriol, B. Monsarrat, G. Delsol, B. Payrastre, and D. Morello A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK Blood, October 15, 2006; 108(8): 2780 - 2788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Corcoran, W.-L. Hsu, and J. R. Smiley Herpes Simplex Virus ICP27 Is Required for Virus-Induced Stabilization of the ARE-Containing IEX-1 mRNA Encoded by the Human IER3 Gene J. Virol., October 1, 2006; 80(19): 9720 - 9729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Fiol, S. Y. Chan, and D. Kultz Regulation of osmotic stress transcription factor 1 (Ostf1) in tilapia (Oreochromis mossambicus) gill epithelium during salinity stress J. Exp. Biol., August 15, 2006; 209(16): 3257 - 3265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. A. Koo, P. McPoland, J. P. Wagoner, O. J. Kane, V. Lohmann, and S. J. Polyak Relationships between Hepatitis C Virus Replication and CXCL-8 Production In Vitro. J. Virol., August 1, 2006; 80(16): 7885 - 7893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Harris, Z. Zhang, B. Chaubey, and V. N. Pandey Identification of Cellular Factors Associated with the 3'-Nontranslated Region of the Hepatitis C Virus Genome Mol. Cell. Proteomics, June 1, 2006; 5(6): 1006 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Prechtel, J. Chemnitz, S. Schirmer, C. Ehlers, I. Langbein-Detsch, J. Stulke, M.-C. Dabauvalle, R. H. Kehlenbach, and J. Hauber Expression of CD83 Is Regulated by HuR via a Novel cis-Active Coding Region RNA Element J. Biol. Chem., April 21, 2006; 281(16): 10912 - 10925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fahling, R. Mrowka, A. Steege, P. Martinka, P. B. Persson, and B. J. Thiele Heterogeneous Nuclear Ribonucleoprotein-A2/B1 Modulate Collagen Prolyl 4-Hydroxylase, {alpha} (I) mRNA Stability J. Biol. Chem., April 7, 2006; 281(14): 9279 - 9286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ratti, C. Fallini, L. Cova, R. Fantozzi, C. Calzarossa, E. Zennaro, A. Pascale, A. Quattrone, and V. Silani A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA. J. Cell Sci., April 1, 2006; 119(Pt 7): 1442 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hitti, T. Iakovleva, M. Brook, S. Deppenmeier, A. D. Gruber, D. Radzioch, A. R. Clark, P. J. Blackshear, A. Kotlyarov, and M. Gaestel Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol. Cell. Biol., March 1, 2006; 26(6): 2399 - 2407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Barreau, L. Paillard, and H. B. Osborne AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res., January 3, 2006; 33(22): 7138 - 7150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Jacobs, P. A. Stockwell, W. P. Tate, and C. M. Brown Transterm--extended search facilities and improved integration with other databases Nucleic Acids Res., January 1, 2006; 34(suppl_1): D37 - D40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bakheet, B. R. G. Williams, and K. S. A. Khabar ARED 3.0: the large and diverse AU-rich transcriptome Nucleic Acids Res., January 1, 2006; 34(suppl_1): D111 - D114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Murakami, T. Shigemori, and H. Ohigashi Zingiberaceous and Citrus Constituents, 1'-Acetoxychavicol Acetate, Zerumbone, Auraptene, and Nobiletin, Suppress Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in RAW264.7 Murine Macrophages through Different Modes of Action J. Nutr., December 1, 2005; 135(12): 2987S - 2992S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jeyaraj, D. Dakhlallah, S. R. Hill, and B. S. Lee HuR Stabilizes Vacuolar H+-translocating ATPase mRNA during Cellular Energy Depletion J. Biol. Chem., November 11, 2005; 280(45): 37957 - 37964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fan, N. M. Heller, M. Gorospe, U. Atasoy, and C. Stellato The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy Eur. Respir. J., November 1, 2005; 26(5): 933 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. HU, C. S. LUTZ, J. WILUSZ, and B. TIAN Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation RNA, October 1, 2005; 11(10): 1485 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Z. Xu, S. Di Marco, I. Gallouzi, M. Rola-Pleszczynski, and D. Radzioch RNA-Binding Protein HuR Is Required for Stabilization of SLC11A1 mRNA and SLC11A1 Protein Expression Mol. Cell. Biol., September 15, 2005; 25(18): 8139 - 8149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Linker, A. Pautz, M. Fechir, T. Hubrich, J. Greeve, and H. Kleinert Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR Nucleic Acids Res., August 26, 2005; 33(15): 4813 - 4827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Al-Mohanna, S. Saleh, R. S. Parhar, K. Khabar, and K. Collison Human neutrophil gene expression profiling following xenogeneic encounter with porcine aortic endothelial cells: the occult role of neutrophils in xenograft rejection revealed J. Leukoc. Biol., July 1, 2005; 78(1): 51 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. L. Spurrell, S. Wiehler, R. S. Zaheer, S. P. Sanders, and D. Proud Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L85 - L95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fechir, K. Linker, A. Pautz, T. Hubrich, U. Forstermann, F. Rodriguez-Pascual, and H. Kleinert Tristetraprolin Regulates the Expression of the Human Inducible Nitric-Oxide Synthase Gene Mol. Pharmacol., June 1, 2005; 67(6): 2148 - 2161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-I. Leong and B. Lonnerdal Iron transporters in rat mammary gland: effects of different stages of lactation and maternal iron status Am. J. Clinical Nutrition, February 1, 2005; 81(2): 445 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lykke-Andersen and E. Wagner Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1 Genes & Dev., February 1, 2005; 19(3): 351 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Okazaki, K. Imai, R. F. Kikuno, K. Misawa, M. Kawai, S. Inamoto, R. Ohara, T. Nagase, O. Ohara, and H. Koga Influence of the 3'-UTR-length of mKIAA cDNAs and their Sequence Features to the mRNA Expression Level in the Brain DNA Res, January 1, 2005; 12(3): 181 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Otake, T. K. Sengupta, S. Bandyopadhyay, E. K. Spicer, and D. J. Fernandes Retinoid-Induced Apoptosis in HL-60 Cells Is Associated with Nucleolin Down-Regulation and Destabilization of Bcl-2 mRNA Mol. Pharmacol., January 1, 2005; 67(1): 319 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Guo, J.-W. N. Carroll, M. R. MacDonald, S. P. Goff, and G. Gao The Zinc Finger Antiviral Protein Directly Binds to Specific Viral mRNAs through the CCCH Zinc Finger Motifs J. Virol., December 1, 2004; 78(23): 12781 - 12787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wahl, T. J. Eddinger, and C.-M. Hai Sinusoidal length oscillation- and receptor-mediated mRNA expression of myosin isoforms and {alpha}-SM actin in airway smooth muscle Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1697 - C1708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Fritz, D. Liu, J. Xu, S. Jiang, and M. B. Rogers Conservation of Bmp2 Post-transcriptional Regulatory Mechanisms J. Biol. Chem., November 19, 2004; 279(47): 48950 - 48958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Stellato Post-transcriptional and Nongenomic Effects of Glucocorticoids Proceedings of the ATS, November 1, 2004; 1(3): 255 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arao, A. Kikuchi, M. Kishida, M. Yonekura, A. Inoue, S. Yasuda, S. Wada, K. Ikeda, and F. Kayama Stability of A+U-Rich Element Binding Factor 1 (AUF1)-Binding Messenger Ribonucleic Acid Correlates with the Subcellular Relocalization of AUF1 in the Rat Uterus upon Estrogen Treatment Mol. Endocrinol., September 1, 2004; 18(9): 2255 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. V. Reddy, G. Bhattacharjee, G. Schabbauer, A. Hollis, K. Kempf, M. Tencati, M. O'Connell, M. Guha, and N. Mackman Dexamethasone enhances LPS induction of tissue factor expression in human monocytic cells by increasing tissue factor mRNA stability J. Leukoc. Biol., July 1, 2004; 76(1): 145 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ma, X. Cui, S. Wang, J. Zhang, E. V. Nishanian, W. Wang, R. A. Wesley, and R. L. Danner Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation J. Leukoc. Biol., July 1, 2004; 76(1): 278 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Brooks, J. E. Connolly, and W. F. C. Rigby The Role of mRNA Turnover in the Regulation of Tristetraprolin Expression: Evidence for an Extracellular Signal-Regulated Kinase-Specific, AU-Rich Element-Dependent, Autoregulatory Pathway J. Immunol., June 15, 2004; 172(12): 7263 - 7271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Winzen, G. Gowrishankar, F. Bollig, N. Redich, K. Resch, and H. Holtmann Distinct Domains of AU-Rich Elements Exert Different Functions in mRNA Destabilization and Stabilization by p38 Mitogen-Activated Protein Kinase or HuR Mol. Cell. Biol., June 1, 2004; 24(11): 4835 - 4847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Donnini, A. Lapucci, L. Papucci, E. Witort, A. Jacquier, G. Brewer, A. Nicolin, S. Capaccioli, and N. Schiavone Identification of TINO: A NEW EVOLUTIONARILY CONSERVED BCL-2 AU-RICH ELEMENT RNA-BINDING PROTEIN J. Biol. Chem., May 7, 2004; 279(19): 20154 - 20166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kimura, I. Hashimoto, T. Nagase, and J.-I. Fujisawa CRM1-dependent, but not ARE-mediated, nuclear export of IFN-{alpha}1 mRNA J. Cell Sci., May 1, 2004; 117(11): 2259 - 2270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S.A. KHABAR, M. DHALLA, L. AL-HAJ, T. BAKHEET, C. SY, and M. NAEMMUDDIN Selection of AU-rich transiently expressed sequences: Reversal of cDNA abundance RNA, April 1, 2004; 10(4): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Cok, S. J. Acton, A. E. Sexton, and A. R. Morrison Identification of RNA-binding Proteins in RAW 264.7 Cells That Recognize a Lipopolysaccharide-responsive Element in the 3-Untranslated Region of the Murine Cyclooxygenase-2 mRNA J. Biol. Chem., February 27, 2004; 279(9): 8196 - 8205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Russell, D. S. Cunninghame Graham, C. Shepherd, C. A. Roberton, J. Whittaker, J. Meeks, R. J. Powell, D. A. Isenberg, M. J. Walport, and T. J. Vyse Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus Hum. Mol. Genet., January 1, 2004; 13(1): 137 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Schor, I. R. Ellis, S. J. Jones, R. Baillie, K. Seneviratne, J. Clausen, K. Motegi, B. Vojtesek, K. Kankova, E. Furrie, et al. Migration-Stimulating Factor: A Genetically Truncated Onco-Fetal Fibronectin Isoform Expressed by Carcinoma and Tumor-Associated Stromal Cells Cancer Res., December 15, 2003; 63(24): 8827 - 8836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. van Pesch and T. Michiels Characterization of Interferon-{alpha} 13, a Novel Constitutive Murine Interferon-{alpha} Subtype J. Biol. Chem., November 21, 2003; 278(47): 46321 - 46328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. van der Giessen, S. Di-Marco, E. Clair, and I. E. Gallouzi RNAi-mediated HuR Depletion Leads to the Inhibition of Muscle Cell Differentiation J. Biol. Chem., November 21, 2003; 278(47): 47119 - 47128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ruggiero, M. Olivero, A. Follenzi, L. Naldini, R. Calogero, and M. F. Di Renzo Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR Nucleic Acids Res., November 15, 2003; 31(22): 6561 - 6569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Park-Lee, S. Kim, and I. A. Laird-Offringa Characterization of the Interaction between Neuronal RNA-binding Protein HuD and AU-rich RNA J. Biol. Chem., October 10, 2003; 278(41): 39801 - 39808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sarkar, Q. Xi, C. He, and R. J. Schneider Selective Degradation of AU-Rich mRNAs Promoted by the p37 AUF1 Protein Isoform Mol. Cell. Biol., September 15, 2003; 23(18): 6685 - 6693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Yang, E. van Nimwegen, M. Zavolan, N. Rajewsky, M. Schroeder, M. Magnasco, and J. E. Darnell Jr Decay Rates of Human mRNAs: Correlation With Functional Characteristics and Sequence Attributes Genome Res., August 1, 2003; 13(8): 1863 - 1872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Nabors, E. Suswam, Y. Huang, X. Yang, M. J. Johnson, and P. H. King Tumor Necrosis Factor {alpha} Induces Angiogenic Factor Up-Regulation in Malignant Glioma Cells: A Role for RNA Stabilization and HuR Cancer Res., July 15, 2003; 63(14): 4181 - 4187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Lai, E. A. Kennington, and P. J. Blackshear Tristetraprolin and Its Family Members Can Promote the Cell-Free Deadenylation of AU-Rich Element-Containing mRNAs by Poly(A) Ribonuclease Mol. Cell. Biol., June 1, 2003; 23(11): 3798 - 3812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Blackshear, W. S. Lai, E. A. Kennington, G. Brewer, G. M. Wilson, X. Guan, and P. Zhou Characteristics of the Interaction of a Synthetic Human Tristetraprolin Tandem Zinc Finger Peptide with AU-rich Element-containing RNA Substrates J. Biol. Chem., May 23, 2003; 278(22): 19947 - 19955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. A. Khabar, Y. M. Siddiqui, F. Al-Zoghaibi, L. Al-Haj, M. Dhalla, A. Zhou, B. Dong, M. Whitmore, J. Paranjape, M. N. Al-Ahdal, et al. RNase L Mediates Transient Control of the Interferon Response through Modulation of the Double-stranded RNA-dependent Protein Kinase PKR J. Biol. Chem., May 23, 2003; 278(22): 20124 - 20132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yu, S. Stasinopoulos, P. Leedman, and R. L. Medcalf Inherent Instability of Plasminogen Activator Inhibitor Type 2 mRNA Is Regulated by Tristetraprolin J. Biol. Chem., April 11, 2003; 278(16): 13912 - 13918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tebo, S. Der, M. Frevel, K. S. A. Khabar, B. R. G. Williams, and T. A. Hamilton Heterogeneity in Control of mRNA Stability by AU-rich Elements J. Biol. Chem., March 28, 2003; 278(14): 12085 - 12093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. E. Frevel, T. Bakheet, A. M. Silva, J. G. Hissong, K. S. A. Khabar, and B. R. G. Williams p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts Mol. Cell. Biol., January 15, 2003; 23(2): 425 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bakheet, B. R. G. Williams, and K. S. A. Khabar ARED 2.0: an update of AU-rich element mRNA database Nucleic Acids Res., January 1, 2003; 31(1): 421 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Raghavan, R. L. Ogilvie, C. Reilly, M. L. Abelson, S. Raghavan, J. Vasdewani, M. Krathwohl, and P. R. Bohjanen Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes Nucleic Acids Res., December 15, 2002; 30(24): 5529 - 5538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Marion, P. J. Kaisaki, V. Pouillon, C. Gueydan, J. C. Levy, A. Bodson, G. Krzentowski, J.-C. Daubresse, J. Mockel, J. Behrends, et al. The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man Diabetes, July 1, 2002; 51(7): 2012 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S.A. Khabar, M. Dhalla, T. Bakheet, C. Sy, and L. al-Haj An Integrated Computational and Laboratory Approach for Selective Amplification of mRNAs Containing the Adenylate Uridylate-Rich Element Consensus Sequence Genome Res., June 1, 2002; 12(6): 985 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gouble, S. Grazide, F. Meggetto, P. Mercier, G. Delsol, and D. Morello A New Player in Oncogenesis: AUF1/hnRNPD Overexpression Leads to Tumorigenesis in Transgenic Mice Cancer Res., March 1, 2002; 62(5): 1489 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Jacobs, O. Rackham, P. A. Stockwell, W. Tate, and C. M. Brown Transterm: a database of mRNAs and translational control elements Nucleic Acids Res., January 1, 2002; 30(1): 310 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-K. Rundlof, M. Carlsten, and E. S. J. Arner The Core Promoter of Human Thioredoxin Reductase 1. CLONING, TRANSCRIPTIONAL ACTIVITY, AND Oct-1, Sp1, AND Sp3 BINDING REVEAL A HOUSEKEEPING-TYPE PROMOTER FOR THE AU-RICH ELEMENT-REGULATED GENE J. Biol. Chem., August 3, 2001; 276(32): 30542 - 30551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Marion, P. J. Kaisaki, V. Pouillon, C. Gueydan, J. C. Levy, A. Bodson, G. Krzentowski, J.-C. Daubresse, J. Mockel, J. Behrends, et al. The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man Diabetes, July 1, 2002; 51(7): 2012 - 2017. [Abstract] [Full Text] [PDF]
|
|