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Nucleic Acids Research, 2001, Vol. 29, No. 1 29-32
© 2001 Oxford University Press

Protein Information Resource: a community resource for expert annotation of protein data

Winona C. Barker*, John S. Garavelli, Zhenglin Hou, Hongzhan Huang, Robert S. Ledley, Peter B. McGarvey, Hans-Werner Mewes1, Bruce C. Orcutt, Friedhelm Pfeiffer1, Akira Tsugita2, C. R. Vinayaka, Chunlin Xiao, Lai-Su L. Yeh and Cathy Wu

National Biomedical Research Foundation, 3900 Reservoir Road, LR-3, NW, Washington, DC 20007, USA, 1GSF-Forschungszentrum f. Umwelt und Gesundheit, Munich Information Center for Protein Sequences am Max-Planck-Instut für Biochemie, Am Klopferspitz 18, D-82152 Martinsried, Germany and 2Japan International Protein Information Database, Proteomics Research Laboratory, Tsukuba, Japan

The Protein Information Resource, in collaboration with the Munich Information Center for Protein Sequences (MIPS) and the Japan International Protein Information Database (JIPID), produces the most comprehensive and expertly annotated protein sequence database in the public domain, the PIR-International Protein Sequence Database. To provide timely and high quality annotation and promote database interoperability, the PIR-International employs rule-based and classification-driven procedures based on controlled vocabulary and standard nomenclature and includes status tags to distinguish experimentally determined from predicted protein features. The database contains about 200 000 non-redundant protein sequences, which are classified into families and superfamilies and their domains and motifs identified. Entries are extensively cross-referenced to other sequence, classification, genome, structure and activity databases. The PIR web site features search engines that use sequence similarity and database annotation to facilitate the analysis and functional identification of proteins. The PIR-Inter­national databases and search tools are accessible on the PIR web site at http://pir.georgetown.edu/ and at the MIPS web site at http://www.mips.biochem.mpg.de. The PIR-International Protein Sequence Database and other files are also available by FTP.

* To whom correspondence should be addressed. Tel: +1 202 687 2121; Fax: +1 202 687 1662; Email: pirmail{at}nbrf.georgetown.edu


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