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Nucleic Acids Research, 2001, Vol. 29, No. 1 300-302
© 2001 Oxford University Press

OrCGDB: a database of genes involved in oral cancer

Alan E. Levine* and David L. Steffen1

Department of Basic Sciences, The University of Texas Health Science Center Houston, Dental Branch, Houston, TX 77030, USA and 1Biomedical Computing, Houston, TX 77005, USA

The Oral Cancer Gene Database (OrCGDB; http://www.tumor-gene.org/Oral/oral.html) was developed to provide the biomedical community with easy access to the latest information on the genes involved in oral cancer. The information is stored in a relational database and accessed through a WWW interface. The OrCGDB is organized by gene name, which is linked to information describing properties of the gene. This information is stored as a collection of findings (‘facts’) that are entered by the database curator in a semi-structured format from information in primary publications using a WWW interface. These facts include causes of oncogenic activation, chromosomal localization of the gene, mutations associated with the gene, the biochemical identity and activity of the gene product, synonyms for the gene name and a variety of clinical information. Each fact is associated with a MEDLINE citation. The user can search the OrCGDB by gene name or by entering a textword. The OrCGDB is part of a larger WWW-based tumor gene database and represents a new approach to catalog and display the research literature.

* To whom correspondence should be addressed. Tel: +1 713 500 4497; Fax: +1 713 500 4500; Email: alevine{at}mail.db.uth.tmc.edu


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