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Nucleic Acids Research, 2001, Vol. 29, No. 12 2437-2447
© 2001 Oxford University Press

Survey and Summary

SURVEY AND SUMMARY

The applications of universal DNA base analogues

David Loakes*

Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

A universal base analogue forms ‘base pairs’ with each of the natural DNA/RNA bases with little discrimination between them. A number of such analogues have been prepared and their applications as biochemical tools investigated. Most of these analogues are non-hydrogen bonding, hydrophobic, aromatic ‘bases’ which stabilise duplex DNA by stacking interactions. This review of the literature of universal bases (to 2000) details the analogues investigated, and their uses and limitations are discussed.

* Tel: +44 1223 402206; Fax: +44 1223 412178; Email: dml{at}mrc-lmb.cam.ac.uk


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