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Nucleic Acids Research, 2001, Vol. 29, No. 24 5195-5206
© 2001 Oxford University Press

Comparative analysis of FUR regulons in gamma-proteobacteria

E. M. Panina*, A. A. Mironov1 and M. S. Gelfand1

State Scientific Center GosNIIGenetika and 1IntegratedGenomics-Moscow, 1st Dorozhny prospect, Moscow 113545, Russia

Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.cholerae that is probably involved in the process of pathogenesis.

* To whom correspondence should be addressed. Tel: +7 095 315 01 56; Fax: +7 095 315 05 01; Email: katya{at}ekpanina.mccme.ru Correspondence may also be addressed to M. S. Gelfand. Tel: +7 095 315 0156; Fax: +7 095 315 0501; Email: misha@imb.imb.ac.ru


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